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Previous Volume 341:362-363 July 29, 1999 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The treatment of fever and neutropenia has evolved with the development of both new antimicrobial drugs and new strategies for using them. More than three decades ago, Bodey and colleagues identified the association between neutropenia and serious infection in patients with cancer as such patients began to be treated with intensive cytotoxic chemotherapy and given platelet transfusions to prevent death from bleeding.¹ The first effective treatment for patients with fever and neutropenia was the combination of an antipseudomonal penicillin, carbenicillin, and gentamicin in a strategy of early empirical therapy triggered by fever alone.² The studies of Pizzo and colleagues refined . . . [Full Text of this Article]

References

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• Moores, K. G. (2007). Safe and effective outpatient treatment of adults with chemotherapy-induced neutropenic fever. Am J Health Syst Pharm 64: 717-722 [Abstract] [Full Text]  
• Ouvrier, M.-J., Thery, J.-C., Blot, E. (2006). Outpatient Oral Antibiotics for Febrile Neutropenic Cancer Patients. JCO 24: 5614-5614 [Full Text]  
• Klastersky, J., Paesmans, M., Georgala, A., Muanza, F., Plehiers, B., Dubreucq, L., Lalami, Y., Aoun, M., Barette, M. (2006). Outpatient Oral Antibiotics for Febrile Neutropenic Cancer Patients Using a Score Predictive for Complications. JCO 24: 4129-4134 [Abstract] [Full Text]  
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• Peacock, J. E. Jr., Herrington, D. A., Wade, J. C., Lazarus, H. M., Reed, M. D., Sinclair, J. W., Haverstock, D. C., Kowalsky, S. F., Hurd, D. D., Cushing, D. A., Harman, C. P., Donowitz, G. R. (2002). Ciprofloxacin plus Piperacillin Compared with Tobramycin plus Piperacillin as Empirical Therapy in Febrile Neutropenic Patients: A Randomized, Double-Blind Trial. ANN INTERN MED 137: 77-87 [Abstract] [Full Text]  
• Santolaya, M. E., Alvarez, A. M., Becker, A., Cofre, J., Enriquez, N., O'Ryan, M., Paya, E., Pilorget, J., Salgado, C., Tordecilla, J., Varas, M., Villarroel, M., Viviani, T., Zubieta, M. (2001). Prospective, Multicenter Evaluation of Risk Factors Associated With Invasive Bacterial Infection in Children With Cancer, Neutropenia, and Fever. JCO 19: 3415-3421 [Abstract] [Full Text]  
• Elting, L. S., Rubenstein, E. B., Rolston, K., Cantor, S. B., Martin, C. G., Kurtin, D., Rodriguez, S., Lam, T., Kanesan, K., Bodey, G. (2000). Time to Clinical Response: An Outcome of Antibiotic Therapy of Febrile Neutropenia With Implications for Quality and Cost of Care. JCO 18: 3699-3706 [Abstract] [Full Text]  
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