Tumor Content of the Antiapoptosis Molecule Survivin and Recurrence of Bladder Cancer

doi:10.1056/NEJM199908053410614

Volume 341:452-453		August 5, 1999		Number 6

Tumor Content of the Antiapoptosis Molecule Survivin and Recurrence of Bladder Cancer

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To the Editor: Transitional-cell carcinoma of the bladder isthe fourth most common cancer among American men, with approximately50,000 new cases and 10,500 deaths from the disease every year.Fifty to 80 percent of affected patients have local recurrenceof tumor, an event that frequently heralds muscle invasion andmetastatic disease. Despite the search for markers that canbe used to predict disease progression, no single molecule studiedto date has been shown to identify patients at high risk forrecurrences.¹ Recently, a newly identified inhibitor of apoptosis,²survivin, was found to be expressed in many cancers but not. . . [Full Text of this Article]

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