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Previous Volume 341:536-538 August 12, 1999 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We do not agree with Lagergren et al. (March 18 issue)¹ that the risk of esophageal adenocarcinoma is independent of Barrett's esophagus. We would suggest that gastroesophageal reflux disease causes Barrett's esophagus and that it is the key intermediary step in the development of esophageal adenocarcinoma. Short-segment Barrett's esophagus is now recognized to occur in one fifth to one third of patients with gastroesophageal reflux disease.^2,3 Cameron et al. have shown that most esophageal adenocarcinomas tend to be located near the esophagogastric junction, precisely the area where short-segment Barrett's esophagus is likely to be found.⁴ If gastroesophageal . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Fitzgerald, R C, Abdalla, S, Onwuegbusi, B A, Sirieix, P, Saeed, I T, Burnham, W R, Farthing, M J G (2002). Inflammatory gradient in Barrett's oesophagus: implications for disease complications. Gut 51: 316-322 [Abstract] [Full Text]