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Previous Volume 341:577-585 August 19, 1999 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Heart failure is a major cause of cardiovascular mortality and morbidity, resulting in more than 1 million hospitalizations per year, and is the most common hospital-discharge diagnosis among patients older than 65 years.¹ In recent years, much has been learned about the pathophysiology of heart failure, particularly in the area of fluid and electrolyte metabolism, and this will be the focus of the present review.

Regulation of Body-Fluid Volume

There is considerable evidence in support of a unifying hypothesis of the regulation of body-fluid volume that is applicable to patients with edematous disorders such as cardiac failure, to patients with cirrhosis, and to normal . . . [Full Text of this Article]

Arterial Underfilling

The Sympathetic Nervous System

The Renin–Angiotensin–Aldosterone System

Nonosmotic Release of Arginine Vasopressin

Natriuretic Peptides

Endothelial Hormones

Conclusions

Source Information

From the Department of Medicine, University of Colorado School of Medicine, Denver (R.W.S.); and the Section of Heart Failure and Cardiac Transplantation, University of Cincinnati College of Medicine, Cincinnati (W.T.A.).

Address reprint requests to Dr. Schrier at the Department of Medicine, Box B-178, University of Colorado School of Medicine, 4200 E. 9th Ave., Denver, CO 80262, or at robertschrier@uchsc.edu.

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