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Previous Volume 341:586-592 August 19, 1999 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Disseminated intravascular coagulation is characterized by the widespread activation of coagulation, which results in the intravascular formation of fibrin and ultimately thrombotic occlusion of small and midsize vessels.^1,2,3 Intravascular coagulation can also compromise the blood supply to organs and, in conjunction with hemodynamic and metabolic derangements, may contribute to the failure of multiple organs. At the same time, the use and subsequent depletion of platelets and coagulation proteins resulting from the ongoing coagulation may induce severe bleeding (Figure 1). Bleeding may be the presenting symptom in a patient with disseminated intravascular coagulation, a factor that can complicate decisions . . . [Full Text of this Article]

Associated Clinical Conditions and Incidence

Infectious Disease

Severe Trauma

Cancer

Obstetrical Disorders

Giant Hemangiomas

Microangiopathic Hemolytic Anemia

Clinical Relevance and Prognosis

Pathogenesis

Generation of Thrombin

Defects in Inhibitors of Coagulation

Fibrinolytic Defect

Diagnosis

Management

Anticoagulants

Platelets and Plasma

Concentrates of Coagulation Inhibitors

Antifibrinolytic Agents

Future Therapeutic Options

Source Information

From the Department of Vascular Medicine and Internal Medicine, Academic Medical Center, University of Amsterdam (M.L., H.C.), and the Department of Internal Medicine, Slotervaart Hospital (H.C.) — both in Amsterdam.

Address reprint requests to Dr. Levi at the Department of Vascular Medicine and Internal Medicine, Academic Medical Centre F-4, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands, or at m.m.levi@amc.uva.nl.

References

Related Letters:

Disseminated Intravascular Coagulation
Schmaier A. H., Levi M., ten Cate H.
Extract | Full Text  
N Engl J Med 1999; 341:1937-1938, Dec 16, 1999. Correspondence

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