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Previous Volume 341:609-610 August 19, 1999 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by D'Onofrio, G. Related Article by D'Onofrio, G. PubMed Citation

To the Editor: D'Onofrio et al. (March 25 issue)¹ found that treatment with intravenous lorazepam is associated with a significant reduction in the risk of recurrent seizures related to alcohol. They studied patients with a history of chronic alcohol abuse who presented to the emergency departments of two hospitals in Boston after a witnessed, generalized seizure.

My first shock (of many) was that the patients were randomly assigned to receive either lorazepam or a saline placebo, even though it was recognized that without treatment a much higher rate of seizures was expected. I was anticipating a dose–response study or a . . . [Full Text of this Article]

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