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Previous Volume 342:21-27 January 6, 2000 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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There are many types of cerebellar ataxia, including ataxia due to congenital or metabolic disorders and a paraneoplastic form in patients with gynecologic cancer, breast cancer, lung cancer, or Hodgkin's disease.¹ This paraneoplastic syndrome is the only type of cerebellar ataxia associated with autoantibodies against neuronal antigens. Often, the neuronal antigens are aberrantly expressed by the tumor cells.^2,3,4 The antineuronal autoantibodies are believed to cause cerebellar ataxia, but this is unproved.^5,6 In Hodgkin's disease, the lymphoma precedes the ataxia by months to years in 80 percent of patients, and ataxia often occurs during a prolonged complete remission.⁴ Among patients with . . . [Full Text of this Article]

Case Reports

Patient 1

Patient 2

Methods

Samples

Immunohistochemical Analysis

Cell Labeling and Assay for Inositol Phosphates

Absorption Experiments

Transfer Experiments

Expression of mGluR1 in Tumor Samples

Results

Discussion

Source Information

From the Departments of Neuro-Oncology (P.S.S., B.D.L., W.M., M.C., C.V.) and Pathology (S.H.-L.), Daniel den Hoed Cancer Center, University Hospital Rotterdam, the Netherlands; the Departments of Immunology (B.D.L.) and Anatomy (M.C., D.J., C.D.Z.), Erasmus University Rotterdam, the Netherlands; the Departments of Morphologic Brain Science (A.K., R.S.) and Biologic Sciences (N.S., S.N.), Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan; and the Laboratory of Cerebral Structure, National Institute for Physiologic Sciences, Myodaiji, Okazaki, Japan (A.K., R.S.). Drs. Sillevis Smitt and Kinoshita contributed equally to the article.

Address reprint requests to Dr. Sillevis Smitt at the Department of Neuro-Oncology, Daniel den Hoed Cancer Center, P.O. Box 5201, 3008 AE Rotterdam, the Netherlands, or at sillevis@neuh.azr.nl.

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