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Previous Volume 342:1215-1216 April 20, 2000 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Eisenberger, M. A. Related Article by Messing, E. M. PubMed Citation

To the Editor: In their report on treatment for prostate cancer after prostatectomy (Dec. 9 issue),¹ Messing et al. conclude that immediate hormonal therapy offers a survival advantage over delayed therapy. There are some basic issues that might call this conclusion into question.

When the Eastern Cooperative Oncology Group designed the study, the biostatistician determined that it would take 220 patients to allow detection of a statistically significant difference at a certain confidence level. That the study enrolled only 100 patients is a substantial deviation from what was thought to be necessary to answer the question. The authors do not . . . [Full Text of this Article]

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