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Previous Volume 342:1218-1219 April 20, 2000 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Germ-line mutations in the RET proto-oncogene are associated with various disease phenotypes including familial medullary thyroid carcinoma and Hirschsprung's disease.¹ Studies have suggested an involvement of RET in the development of the mammalian kidney.^2,3 The RET proto-oncogene encodes a receptor tyrosine kinase that is involved in inductive interactions between the epithelium of the ureteric bud and metanephric mesenchyme, leading to the differentiation of a functional kidney. Although mice lacking functional ret may have renal agenesis or dysgenesis, no clinically relevant renal abnormalities have been reported in patients with familial medullary thyroid carcinoma who had RET mutations.⁴

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