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Previous Volume 342:1292-1293 April 27, 2000 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Milgrom, H. PubMed Citation

To the Editor: Milgrom et al. (Dec. 23 issue)¹ report on the treatment of allergic asthma with monoclonal IgE antibody. It has generally been accepted that IgE has a central role in the pathogenesis of anaphylaxis, allergic rhinitis, and asthma. However, several recent studies seem to question this concept.

Although the role of IgE has been best characterized in the pathogenesis of anaphylaxis and allergic rhinitis, acute anaphylaxis after allergen sensitization has been reported in the absence of IgE in laboratory animals.² Casale et al.³ demonstrated that use of humanized anti-IgE monoclonal antibody in ragweed-sensitive patients with allergic rhinitis, both . . . [Full Text of this Article]

References

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• Marini, A., Agosti, M. (2003). Is Mother's Milk Programmed for Long-Term Results and Prevention of Adult Diseases?. Pediatrics 111: 921-922 [Full Text]  
• Douwes, J, Gibson, P, Pekkanen, J, Pearce, N (2002). Non-eosinophilic asthma: importance and possible mechanisms. Thorax 57: 643-648 [Abstract] [Full Text]