Genetic testing is increasingly being used in the managementof cancer. Cytogenetic and molecular genetic assays now playa part in the diagnosis and monitoring of a variety of leukemias,lymphomas, and solid tumors. Moreover, the identification ofinherited mutations of genes that cause susceptibility to cancerprovides new tools for the prevention and early detection ofcancer.1 The study by Gryfe et al. in this issue of the Journalconcerns the prognostic importance of a genetic abnormality(microsatellite instability) that occurs not only in hereditarynonpolyposis colorectal cancer but also in colorectal tumorsin young patients (50 years of . . . [Full Text of this Article]
Offit, K.
(2004). MSH6 Mutations in Hereditary Nonpolyposis Colon Cancer: Another Slice of the Pie. JCO
22: 4449-4451
[Full Text]
Jantscheff, P., Terracciano, L., Lowy, A., Glatz-Krieger, K., Grunert, F., Micheel, B., Brummer, J., Laffer, U., Metzger, U., Herrmann, R., Rochlitz, C.
(2003). Expression of CEACAM6 in Resectable Colorectal Cancer: A Factor of Independent Prognostic Significance. JCO
21: 3638-3646
[Abstract][Full Text]
Samowitz, W. S., Curtin, K., Ma, K.-N., Schaffer, D., Coleman, L. W., Leppert, M., Slattery, M. L.
(2001). Microsatellite Instability in Sporadic Colon Cancer Is Associated with an Improved Prognosis at the Population Level. Cancer Epidemiol. Biomarkers Prev.
10: 917-923
[Abstract][Full Text]
Offit, K.
(2000). Are BRCA1- and BRCA2-Associated Breast Cancers Different?. JCO
18: 104s-106
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