Preterm delivery is the chief problem in obstetrics today, accountingfor 70 percent of perinatal mortality and nearly half of long-termneurologic morbidity.1,2 Approximately 10 percent of all birthsare preterm, but most of the serious illness and death is concentratedin the 1 to 2 percent of infants who are born at less than 32weeks of gestation and who weigh less than 1500 g. Approximately20 percent of preterm births are the result of a physician'sdecision to bring about delivery for maternal or fetal indications,and the remainder follow the spontaneous onset of labor or ruptureof . . . [Full Text of this Article]
Epidemiology
Organisms
Timing of Infection
Bacterial Vaginosis
Mechanisms of Preterm Delivery Due to Infection
Markers of Infection
Treatment of Infection to Prevent Preterm Delivery
Conclusions
Source Information
From the Department of Obstetrics and Gynecology and the Center for Research on Women's Health, University of Alabama at Birmingham, Birmingham.
Address reprint requests to Dr. Goldenberg at the Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 618 S. 20th St., OHB 560, Birmingham, AL 35233-7333, or at rlg@uab.edu.
References
This article has been cited by other articles:
Jabbour, H. N, Sales, K. J, Catalano, R. D, Norman, J. E
(2009). Inflammatory pathways in female reproductive health and disease. Reproduction
138: 903-919
[Abstract][Full Text]
Boyd, H. A., Poulsen, G., Wohlfahrt, J., Murray, J. C., Feenstra, B., Melbye, M.
(2009). Maternal Contributions to Preterm Delivery. Am J Epidemiol
170: 1358-1364
[Abstract][Full Text]
Kramer, M. R., Hogue, C. R.
(2009). What Causes Racial Disparities in Very Preterm Birth? A Biosocial Perspective. Epidemiol Rev
31: 84-98
[Abstract][Full Text]
Mitchell, B. F., Taggart, M. J.
(2009). Are animal models relevant to key aspects of human parturition?. Am. J. Physiol. Regul. Integr. Comp. Physiol.
297: R525-R545
[Abstract][Full Text]
Kallapur, S. G., Moss, T. J. M., Auten, R. L. Jr., Nitsos, I., Pillow, J. J., Kramer, B. W., Maeda, D. Y., Newnham, J. P., Ikegami, M., Jobe, A. H.
(2009). IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung. Am. J. Physiol. Lung Cell. Mol. Physiol.
297: L512-L519
[Abstract][Full Text]
Snegovskikh, V. V., Schatz, F., Arcuri, F., Toti, P., Kayisli, U. A., Murk, W., Guoyang Luo, , Lockwood, C. J., Norwitz, E. R.
(2009). Intra-Amniotic Infection Upregulates Decidual Cell Vascular Endothelial Growth Factor (VEGF) and Neuropilin-1 and -2 Expression: Implications for Infection-Related Preterm Birth. Reproductive Sciences
16: 767-780
[Abstract]
Thaxton, J. E., Romero, R., Sharma, S.
(2009). TLR9 Activation Coupled to IL-10 Deficiency Induces Adverse Pregnancy Outcomes. J. Immunol.
183: 1144-1154
[Abstract][Full Text]
Strickland, M J, Klein, M, Darrow, L A, Flanders, W D, Correa, A, Marcus, M, Tolbert, P E
(2009). The issue of confounding in epidemiological studies of ambient air pollution and pregnancy outcomes. J. Epidemiol. Community Health
63: 500-504
[Abstract][Full Text]
Katz, J., Chegini, N., Shiverick, K.T., Lamont, R.J.
(2009). Localization of P. gingivalis in Preterm Delivery Placenta. JDR
88: 575-578
[Abstract][Full Text]
Kallapur, S. G., Nitsos, I., Moss, T. J. M., Polglase, G. R., Pillow, J. J., Cheah, F.-C., Kramer, B. W., Newnham, J. P., Ikegami, M., Jobe, A. H.
(2009). IL-1 Mediates Pulmonary and Systemic Inflammatory Responses to Chorioamnionitis Induced by Lipopolysaccharide. Am. J. Respir. Crit. Care Med.
179: 955-961
[Abstract][Full Text]
Arcuri, F., Toti, P., Buchwalder, L., Casciaro, A., Cintorino, M., Schatz, F., Rybalov, B., Lockwood, C. J.
(2009). Mechanisms of Leukocyte Accumulation and Activation in Chorioamnionitis: Interleukin 1{beta} and Tumor Necrosis Factor {alpha} Enhance Colony Stimulating Factor 2 Expression in Term Decidua. Reproductive Sciences
16: 453-461
[Abstract]
Bizargity, P., Del Rio, R., Phillippe, M., Teuscher, C., Bonney, E. A.
(2009). Resistance to Lipopolysaccharide-Induced Preterm Delivery Mediated by Regulatory T Cell Function in Mice. Biol. Reprod.
80: 874-881
[Abstract][Full Text]
Been, J V, Zimmermann, L J I
(2009). Histological chorioamnionitis and respiratory outcome in preterm infants. Arch. Dis. Child. Fetal Neonatal Ed.
94: F218-F225
[Abstract][Full Text]
Kramer, B. W., Kallapur, S. G., Moss, T. J., Nitsos, I., Newnham, J. P., Jobe, A. H.
(2009). Intra-amniotic LPS modulation of TLR signaling in lung and blood monocytes of fetal sheep. Innate Immunity
15: 101-107
[Abstract]
Herath, S., Lilly, S. T., Fischer, D. P., Williams, E. J., Dobson, H., Bryant, C. E., Sheldon, I. M.
(2009). Bacterial Lipopolysaccharide Induces an Endocrine Switch from Prostaglandin F2{alpha} to Prostaglandin E2 in Bovine Endometrium. Endocrinology
150: 1912-1920
[Abstract][Full Text]
Lohsoonthorn, V., Kungsadalpipob, K., Chanchareonsook, P., Limpongsanurak, S., Vanichjakvong, O., Sutdhibhisal, S., Wongkittikraiwan, N., Sookprome, C., Kamolpornwijit, W., Jantarasaengaram, S., Manotaya, S., Siwawej, V., Barlow, W. E., Fitzpatrick, A. L., Williams, M. A.
(2009). Is Maternal Periodontal Disease a Risk Factor for Preterm Delivery?. Am J Epidemiol
169: 731-739
[Abstract][Full Text]
Yellon, S. M., Ebner, C. A., Elovitz, M. A.
(2009). Medroxyprogesterone Acetate Modulates Remodeling, Immune Cell Census, and Nerve Fibers in the Cervix of a Mouse Model for Inflammation-induced Preterm Birth. Reproductive Sciences
16: 257-264
[Abstract]
Cheah, F.-C., Pillow, J. J., Kramer, B. W., Polglase, G. R., Nitsos, I., Newnham, J. P., Jobe, A. H., Kallapur, S. G.
(2009). Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis. Am. J. Physiol. Lung Cell. Mol. Physiol.
296: L384-L393
[Abstract][Full Text]
Challis, J. R., Lockwood, C. J., Myatt, L., Norman, J. E., Strauss, J. F. III, Petraglia, F.
(2009). Inflammation and Pregnancy. Reproductive Sciences
16: 206-215
[Abstract]
Sata, F., Toya, S., Yamada, H., Suzuki, K., Saijo, Y., Yamazaki, A., Minakami, H., Kishi, R.
(2009). Proinflammatory cytokine polymorphisms and the risk of preterm birth and low birthweight in a Japanese population. Mol Hum Reprod
15: 121-130
[Abstract][Full Text]
Qiu, X., Zhu, L., Pollard, J. W.
(2009). Colony-Stimulating Factor-1-Dependent Macrophage Functions Regulate the Maternal Decidua Immune Responses against Listeria monocytogenes Infections during Early Gestation in Mice. Infect. Immun.
77: 85-97
[Abstract][Full Text]
Han, Y. W., Shen, T., Chung, P., Buhimschi, I. A., Buhimschi, C. S.
(2009). Uncultivated Bacteria as Etiologic Agents of Intra-Amniotic Inflammation Leading to Preterm Birth. J. Clin. Microbiol.
47: 38-47
[Abstract][Full Text]
Shennan, A. H, Chandiramani, M.
(2008). Antibiotics for spontaneous preterm birth. BMJ
337: a3015-a3015
[Full Text]
Menon, R., Fortunato, S. J.
(2008). Induction of Triggering Receptors of Myeloid Cell (TREM-1) Expression in Fetal Membranes and Higher Concentration of Soluble TREM-1 in Amniotic Fluid With Spontaneous Preterm Birth. Reproductive Sciences
15: 825-830
[Abstract]
Yoder, B. A., Albertine, K. H.
(2008). Inflammation and Lung Disease in the Neonatal Period. NeoReviews
9: e447-e457
[Abstract][Full Text]
Wang, W., Yen, H., Chen, C.-H., Soni, R., Jasani, N., Sylvestre, G., Reznik, S. E.
(2008). The Endothelin-Converting Enzyme-1/Endothelin-1 Pathway Plays a Critical Role in Inflammation-Associated Premature Delivery in a Mouse Model. Am. J. Pathol.
173: 1077-1084
[Abstract][Full Text]
Herve, R., Schmitz, T., Evain-Brion, D., Cabrol, D., Leroy, M.-J., Mehats, C.
(2008). The PDE4 Inhibitor Rolipram Prevents NF-{kappa}B Binding Activity and Proinflammatory Cytokine Release in Human Chorionic Cells. J. Immunol.
181: 2196-2202
[Abstract][Full Text]
Blad, S., Welin, A.-K., Kjellmer, I., Rosen, K.G., Mallard, C.
(2008). ECG and Heart Rate Variability Changes in Preterm and Near-Term Fetal Lamb Following LPS Exposure. Reproductive Sciences
15: 572-583
[Abstract]
Abrahams, V. M., Aldo, P. B., Murphy, S. P., Visintin, I., Koga, K., Wilson, G., Romero, R., Sharma, S., Mor, G.
(2008). TLR6 Modulates First Trimester Trophoblast Responses to Peptidoglycan. J. Immunol.
180: 6035-6043
[Abstract][Full Text]
Koga, K., Mor, G.
(2008). Review Article: Expression and Function of Toll-Like Receptors at the Maternal--Fetal Interface. Reproductive Sciences
15: 231-242
[Abstract]
Abrahams, V. M.
(2008). Antagonizing Toll-like Receptors to Prevent Preterm Labor. Reproductive Sciences
15: 108-109
Sun, Y., Vestergaard, M., Pedersen, C. B., Christensen, J., Basso, O., Olsen, J.
(2008). Gestational Age, Birth Weight, Intrauterine Growth, and the Risk of Epilepsy. Am J Epidemiol
167: 262-270
[Abstract][Full Text]
Miralles, R, Hodge, R, Kotecha, S
(2008). Fetal cortisol response to intrauterine microbial colonisation identified by the polymerase chain reaction and fetal inflammation. Arch. Dis. Child. Fetal Neonatal Ed.
93: F51-F54
[Abstract][Full Text]
Kallapur, S. G., Jobe, A. H., Ball, M. K., Nitsos, I., Moss, T. J. M., Hillman, N. H., Newnham, J. P., Kramer, B. W.
(2007). Pulmonary and Systemic Endotoxin Tolerance in Preterm Fetal Sheep Exposed to Chorioamnionitis. J. Immunol.
179: 8491-8499
[Abstract][Full Text]
Chevillard, G., Derjuga, A., Devost, D., Zingg, H. H, Blank, V.
(2007). Identification of interleukin-1{beta} regulated genes in uterine smooth muscle cells. Reproduction
134: 811-822
[Abstract][Full Text]
Catov, J. M., Bodnar, L. M., Ness, R. B., Barron, S. J., Roberts, J. M.
(2007). Inflammation and Dyslipidemia Related to Risk of Spontaneous Preterm Birth. Am J Epidemiol
166: 1312-1319
[Abstract][Full Text]
Eskenazi, B., Marks, A. R., Catalano, R., Bruckner, T., Toniolo, P. G.
(2007). Low birthweight in New York city and upstate New York following the events of September 11th. Hum Reprod
22: 3013-3020
[Abstract][Full Text]
Cockle, J. V., Gopichandran, N., Walker, J. J., Levene, M. I., Orsi, N. M.
(2007). Matrix Metalloproteinases and Their Tissue Inhibitors in Preterm Perinatal Complications. Reproductive Sciences
14: 629-645
[Abstract]
Hillman, N. H., Moss, T. J. M., Kallapur, S. G., Bachurski, C., Pillow, J. J., Polglase, G. R., Nitsos, I., Kramer, B. W., Jobe, A. H.
(2007). Brief, Large Tidal Volume Ventilation Initiates Lung Injury and a Systemic Response in Fetal Sheep. Am. J. Respir. Crit. Care Med.
176: 575-581
[Abstract][Full Text]
Liu, H., Redline, R. W., Han, Y. W.
(2007). Fusobacterium nucleatum Induces Fetal Death in Mice via Stimulation of TLR4-Mediated Placental Inflammatory Response. J. Immunol.
179: 2501-2508
[Abstract][Full Text]
Simhan, H. N., Caritis, S. N.
(2007). Prevention of Preterm Delivery. NEJM
357: 477-487
[Full Text]
Catov, J. M., Bodnar, L. M., Ness, R. B., Markovic, N., Roberts, J. M.
(2007). Association of Periconceptional Multivitamin Use and Risk of Preterm or Small-for-Gestational-Age Births. Am J Epidemiol
166: 296-303
[Abstract][Full Text]
Kramer, B. W., Joshi, S. N., Moss, T. J. M., Newnham, J. P., Sindelar, R., Jobe, A. H., Kallapur, S. G.
(2007). Endotoxin-induced maturation of monocytes in preterm fetal sheep lung. Am. J. Physiol. Lung Cell. Mol. Physiol.
293: L345-L353
[Abstract][Full Text]
Schempf, A. H., Branum, A. M., Lukacs, S. L., Schoendorf, K. C.
(2007). The Contribution of Preterm Birth to the Black-White Infant Mortality Gap, 1990 and 2000. AJPH
97: 1255-1260
[Abstract][Full Text]
Rehan, V. K., Dargan-Batra, S. K., Wang, Y., Cerny, L., Sakurai, R., Santos, J., Beloosesky, R., Gayle, D., Torday, J. S.
(2007). A paradoxical temporal response of the PTHrP/PPAR{gamma} signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung. Am. J. Physiol. Lung Cell. Mol. Physiol.
293: L182-L190
[Abstract][Full Text]
Koga, K., Mor, G.
(2007). Toll-like Receptors and Pregnancy. Reproductive Sciences
14: 297-299
Rizek, R. M., Watson, C. S., Keating, S., Tai, H.-H., Challis, J. R. G., Bocking, A. D.
(2007). 15-Hydroxyprostaglandin Dehydrogenase Protein Expression in Human Fetal Membranes With and Without Subclinical Inflammation. Reproductive Sciences
14: 260-269
[Abstract]
Goldenberg, R. L, Culhane, J. F
(2007). Low birth weight in the United States. Am. J. Clin. Nutr.
85: 584S-590S
[Abstract][Full Text]
Schmitz, T., Souil, E., Herve, R., Nicco, C., Batteux, F., Germain, G., Cabrol, D., Evain-Brion, D., Leroy, M.-J., Mehats, C.
(2007). PDE4 Inhibition Prevents Preterm Delivery Induced by an Intrauterine Inflammation. J. Immunol.
178: 1115-1121
[Abstract][Full Text]
Bry, K., Whitsett, J. A., Lappalainen, U.
(2007). IL-1beta Disrupts Postnatal Lung Morphogenesis in the Mouse. Am. J. Respir. Cell Mol. Bio.
36: 32-42
[Abstract][Full Text]
Rusconi, F., Galassi, C., Forastiere, F., Bellasio, M., De Sario, M., Ciccone, G., Brunetti, L., Chellini, E., Corbo, G., La Grutta, S., Lombardi, E., Piffer, S., Talassi, F., Biggeri, A., Pearce, N., the SIDRIA-2 Collaborative Group,
(2007). Maternal Complications and Procedures in Pregnancy and at Birth and Wheezing Phenotypes in Children. Am. J. Respir. Crit. Care Med.
175: 16-21
[Abstract][Full Text]
Goldenberg, R. L., Culhane, J. F.
(2006). Preterm Birth and Periodontal Disease. NEJM
355: 1925-1927
[Full Text]
Hindle, L. J, Gitau, R., Filteau, S. M, Newens, K. J, Osrin, D., Costello, A. M, Tomkins, A. M, Vaidya, A., Mahato, R. K., Yadav, B., Manandhar, D. S
(2006). Effect of multiple micronutrient supplementation during pregnancy on inflammatory markers in Nepalese women.. Am. J. Clin. Nutr.
84: 1086-1092
[Abstract][Full Text]
Bobetsis, Y. A., Barros, S. P., Offenbacher, S.
(2006). Exploring the relationship between periodontal disease and pregnancy complications. Journal of the American Dental Association
137: 7S-13S
[Abstract][Full Text]
Jobe, A. H.
(2006). The New BPD. NeoReviews
7: e531-e545
[Full Text]
Wang, X., Hagberg, H., Mallard, C., Zhu, C., Hedtjarn, M., Tiger, C.-F., Eriksson, K., Rosen, A., Jacobsson, B.
(2006). Disruption of Interleukin-18, but Not Interleukin-1, Increases Vulnerability to Preterm Delivery and Fetal Mortality after Intrauterine Inflammation. Am. J. Pathol.
169: 967-976
[Abstract][Full Text]
Parry, S., Zhang, J., Koi, H., Arechavaleta-Velasco, F., Elovitz, M. A.
(2006). Transcytosis of Human immunodeficiency virus 1 across the placenta is enhanced by treatment with tumour necrosis factor alpha.. J. Gen. Virol.
87: 2269-2278
[Abstract][Full Text]
Kerk,, J., Dordelmann, M., Bartels, D. B., Brinkhaus, M.-J., Dammann, C. E. L., Dork, T., Dammann, O.
(2006). MUltiplex Measurement of Cytokine/Receptor Gene Polymorphisms and interaction Between Interleukin-10 (-1082) Genotype and Chorioamnionitis in Extreme Preterm Delivery. Reproductive Sciences
13: 350-356
[Abstract]
Ikegami, M., Carter, K., Bishop, K., Yadav, A., Masterjohn, E., Brondyk, W., Scheule, R. K., Whitsett, J. A.
(2006). Intratracheal Recombinant Surfactant Protein D Prevents Endotoxin Shock in the Newborn Preterm Lamb. Am. J. Respir. Crit. Care Med.
173: 1342-1347
[Abstract][Full Text]
Nitsos, I., Rees, S. M., Duncan, J., Kramer, B. W., Harding, R., Newnham, J. P., Moss, T. J. M.
(2006). Chronic Exposure to Intra-Amniotic Lipopolysaccharide Affects the Ovine Fetal Brain. Reproductive Sciences
13: 239-247
[Abstract]
Zhao, B., Koon, D., Bethin, K. E
(2006). Identification of transcription factors at the site of implantation in the later stages of murine pregnancy.. Reproduction
131: 561-571
[Abstract][Full Text]
Kallapur, S G, Jobe, A H
(2006). Contribution of inflammation to lung injury and development.. Arch. Dis. Child. Fetal Neonatal Ed.
91: F132-F135
[Abstract][Full Text]
Malamitsi-Puchner, A., Vrachnis, N., Samoli, E., Baka, S., Hassiakos, D., Creatsas, G.
(2006). Elevated Second Trimester Amniotic Fluid Interferon {gamma}-Inducible T-Cell {alpha} Chhemoattractant Concentrations as a Possible Predictor of Preterm Birth. Reproductive Sciences
13: 25-29
[Abstract]
Richter, O.N., Bartz, C., Dowaji, J., Kupka, M., Reinsberg, J., Ulrich, U., Rath, W.
(2006). Contractile reactivity of human myometrium in isolated non-pregnant uteri. Hum Reprod
21: 36-45
[Abstract][Full Text]
Abrahams, V. M., Visintin, I., Aldo, P. B., Guller, S., Romero, R., Mor, G.
(2005). A Role for TLRs in the Regulation of Immune Cell Migration by First Trimester Trophoblast Cells. J. Immunol.
175: 8096-8104
[Abstract][Full Text]
Pitiphat, W., Gillman, M. W., Joshipura, K. J., Williams, P. L., Douglass, C. W., Rich-Edwards, J. W.
(2005). Plasma C-Reactive Protein in Early Pregnancy and Preterm Delivery. Am J Epidemiol
162: 1108-1113
[Abstract][Full Text]
Kallapur, S. G., Moss, T. J. M., Ikegami, M., Jasman, R. L., Newnham, J. P., Jobe, A. H.
(2005). Recruited Inflammatory Cells Mediate Endotoxin-induced Lung Maturation in Preterm Fetal Lambs. Am. J. Respir. Crit. Care Med.
172: 1315-1321
[Abstract][Full Text]
Thebaud, B., Ladha, F., Michelakis, E. D., Sawicka, M., Thurston, G., Eaton, F., Hashimoto, K., Harry, G., Haromy, A., Korbutt, G., Archer, S. L.
(2005). Vascular Endothelial Growth Factor Gene Therapy Increases Survival, Promotes Lung Angiogenesis, and Prevents Alveolar Damage in Hyperoxia-Induced Lung Injury: Evidence That Angiogenesis Participates in Alveolarization. Circulation
112: 2477-2486
[Abstract][Full Text]
Farhang, L., Weintraub, J. M., Petreas, M., Eskenazi, B., Bhatia, R.
(2005). Association of DDT and DDE with Birth Weight and Length of Gestation in the Child Health and Development Studies, 1959-1967. Am J Epidemiol
162: 717-725
[Abstract][Full Text]
Romero, R., Erez, O., Espinoza, J.
(2005). Intrauterine Infection, Preterm Labor, and Cytokines. Reproductive Sciences
12: 463-465
Olson, D. M.
(2005). The Promise of Prostaglandins: Have They Fulfilled Their Potential as Therapeutic Targets for the Delay of Preterm Birth?. Reproductive Sciences
12: 466-478
[Abstract]
Feigin, R. D.
(2005). Prospects for the Future of Child Health Through Research. JAMA
294: 1373-1379
[Abstract][Full Text]
Helpman, L., Pauzner, D., Lessing, J. B, Kupferminc, M. J, Gutman, G.
(2005). Chorioamnionitis associated with Crohn's disease and azathioprine treatment: a case report. J Med Microbiol
54: 803-804
[Abstract][Full Text]
Shankar, R., Gude, N., Cullinane, F., Brennecke, S., Purcell, A. W, Moses, E. K
(2005). An emerging role for comprehensive proteome analysis in human pregnancy research. Reproduction
129: 685-696
[Abstract][Full Text]
Kallapur, S. G., Nitsos, I., Moss, T. J. M., Kramer, B. W., Newnham, J. P., Ikegami, M., Jobe, A. H.
(2005). Chronic endotoxin exposure does not cause sustained structural abnormalities in the fetal sheep lungs. Am. J. Physiol. Lung Cell. Mol. Physiol.
288: L966-L974
[Abstract][Full Text]
Hirsch, E., Wang, H.
(2005). The Molecular Pathophysiology of Bacterially Induced Preterm Labor: Insights From the Murine Model. Reproductive Sciences
12: 145-155
[Abstract]
Elmes, M., Green, L. R., Poore, K., Newman, J., Burrage, D., Abayasekara, D. R. E., Cheng, Z., Hanson, M. A., Wathes, D. C.
(2005). Raised dietary n-6 polyunsaturated fatty acid intake increases 2-series prostaglandin production during labour in the ewe. J. Physiol.
562: 583-592
[Abstract][Full Text]
Cheng, Z, Elmes, M, Kirkup, S E, Chin, E C, Abayasekara, D R E, Wathes, D C
(2005). The effect of a diet supplemented with the n-6 polyunsaturated fatty acid linoleic acid on prostaglandin production in early- and late-pregnant ewes. J Endocrinol
184: 165-178
[Abstract][Full Text]
Haas, J. S., Fuentes-Afflick, E., Stewart, A. L., Jackson, R. A., Dean, M. L., Brawarsky, P., Escobar, G. J.
(2005). Prepregnancy Health Status and the Risk of Preterm Delivery. Arch Pediatr Adolesc Med
159: 58-63
[Abstract][Full Text]
Goldenberg, R. L., Culhane, J. F.
(2005). Prepregnancy Health Status and the Risk of Preterm Delivery. Arch Pediatr Adolesc Med
159: 89-90
[Full Text]
Kramer, B. W., Ikegami, M., Moss, T. J. M., Nitsos, I., Newnham, J. P., Jobe, A. H.
(2005). Endotoxin-induced Chorioamnionitis Modulates Innate Immunity of Monocytes in Preterm Sheep. Am. J. Respir. Crit. Care Med.
171: 73-77
[Abstract][Full Text]
Abrahams, V. M., Bole-Aldo, P., Kim, Y. M., Straszewski-Chavez, S. L., Chaiworapongsa, T., Romero, R., Mor, G.
(2004). Divergent Trophoblast Responses to Bacterial Products Mediated by TLRs. J. Immunol.
173: 4286-4296
[Abstract][Full Text]
Gravett, M. G., Novy, M. J., Rosenfeld, R. G., Reddy, A. P., Jacob, T., Turner, M., McCormack, A., Lapidus, J. A., Hitti, J., Eschenbach, D. A., Roberts, C. T. Jr, Nagalla, S. R.
(2004). Diagnosis of Intra-amniotic Infection by Proteomic Profiling and Identification of Novel Biomarkers. JAMA
292: 462-469
[Abstract][Full Text]
Hao, K., Wang, X., Niu, T., Xu, X., Li, A., Chang, W., Wang, L., Li, G., Laird, N., Xu, X.
(2004). A candidate gene association study on preterm delivery: application of high-throughput genotyping technology and advanced statistical methods. Hum Mol Genet
13: 683-691
[Abstract][Full Text]
Ikegami, M., Kallapur, S. G., Jobe, A. H.
(2004). Initial responses to ventilation of premature lambs exposed to intra-amniotic endotoxin 4 days before delivery. Am. J. Physiol. Lung Cell. Mol. Physiol.
286: L573-L579
[Abstract][Full Text]
Oger, S., Mehats, C., Barnette, M. S., Ferre, F., Cabrol, D., Leroy, M.-J.
(2004). Anti-Inflammatory and Utero-Relaxant Effects in Human Myometrium of New Generation Phosphodiesterase 4 Inhibitors. Biol. Reprod.
70: 458-464
[Abstract][Full Text]
Wang, H., Hirsch, E.
(2003). Bacterially-Induced Preterm Labor and Regulation of Prostaglandin-Metabolizing Enzyme Expression in Mice: The Role of Toll-Like Receptor 4. Biol. Reprod.
69: 1957-1963
[Abstract][Full Text]
Hernandez-Guerrero, C., Monzon-Bordonaba, F., Jimenez-Zamudio, L., Ahued-Ahued, R., Arechavaleta-Velasco, F., Strauss, J.F. III, Vadillo-Ortega, F.
(2003). In-vitro secretion of proinflammatory cytokines by human amniochorion carrying hyper-responsive gene polymorphisms of tumour necrosis factor-{alpha} and interleukin-1{beta}. Mol Hum Reprod
9: 625-629
[Abstract][Full Text]
Balkundi, D. R, Ziegler, J. A, Watchko, J. F, Craven, C., Trucco, M.
(2003). Regulation of FasL/Fas in Human Trophoblasts: Possible Implications for Chorioamnionitis. Biol. Reprod.
69: 718-724
[Abstract][Full Text]
Gras-Le Guen, C., Debillon, T., Toquet, C., Jarry, A., Winer, N., Jacqueline, C., Kergueris, M. F., Bingen, E., Roze, J. C., Potel, G., Bugnon, D.
(2003). Persistent Bacteremia in Rabbit Fetuses despite Maternal Antibiotic Therapy in a Novel Intrauterine-Infection Model. Antimicrob. Agents Chemother.
47: 2125-2130
[Abstract][Full Text]
Previous
