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It was not long ago that the combination of the words "therapeutics" and "multiple sclerosis" verged on the oxymoronic. If there are investigators who still have this point of view, they are not represented among the authors of the 40 chapters in this well-produced book. The many topics discussed include clinical research methods, outcome measures, and the fine details of magnetic resonance imaging and spectroscopy. It is a sign of the times that three chapters describe the process of drug approval in the United States, Canada, and Europe. The general stance of most of the authors is remarkably upbeat, perhaps
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