FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 342:1568-1571 May 25, 2000 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

The hypereosinophilic syndrome comprises various idiopathic myeloproliferative disorders with sustained eosinophilia and damage to the heart, lungs, skin, and other organs by infiltrating eosinophils.¹ A single mechanism for this syndrome has not been identified, and multiple factors are likely to be involved. The serum level of interleukin-5, an eosinophilopoietic cytokine, is increased in some patients with the hypereosinophilic syndrome,² and a few have been found to have unusual T-cell abnormalities, including CD3–CD4+CD8– T cells^3,4 and so-called double-negative CD3+CD4–CD8– T cells.⁵ CD3, a complex of five proteins associated with the T-cell receptor, is a distinctive feature of all normal T cells. . . . [Full Text of this Article]

Case Report

Results

Discussion

Source Information

From the Department of Medicine, National Naval Medical Center, Bethesda, Md. (M.M.-M., T.B., D.D., K.O.); the Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, Md. (J.M.); the Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Md. (T.F.); and the Infectious Disease Service, Washington Hospital Center, Washington, D.C. (D.L.).

Address reprint requests to Dr. Lucey at the Infectious Disease Service, Rm. 2A-56, Washington Hospital Center, 110 Irving St. NW, Washington, DC 20010.

References

This article has been cited by other articles:

• Tefferi, A., Elliott, M. A., Pardanani, A. (2006). Atypical Myeloproliferative Disorders: Diagnosis and Management. Mayo Clin Proc. 81: 553-563 [Abstract] [Full Text]  
• Ruckert, R., Brandt, K., Braun, A., Hoymann, H.-G., Herz, U., Budagian, V., Durkop, H., Renz, H., Bulfone-Paus, S. (2005). Blocking IL-15 Prevents the Induction of Allergen-Specific T Cells and Allergic Inflammation In Vivo. J. Immunol. 174: 5507-5515 [Abstract] [Full Text]  
• Hoontrakoon, R., Chu, H. W., Gardai, S. J., Wenzel, S. E., McDonald, P., Fadok, V. A., Henson, P. M., Bratton, D. L. (2002). Interleukin-15 Inhibits Spontaneous Apoptosis in Human Eosinophils via Autocrine Production of Granulocyte Macrophage-Colony Stimulating Factor and Nuclear Factor-kappa B Activation. Am. J. Respir. Cell Mol. Bio. 26: 404-412 [Abstract] [Full Text]  
• Ong, P. Y., Hamid, Q. A., Travers, J. B., Strickland, I., Kerithy, M. A., Boguniewicz, M., Leung, D. Y. M. (2002). Decreased IL-15 May Contribute to Elevated IgE and Acute Inflammation in Atopic Dermatitis. J. Immunol. 168: 505-510 [Abstract] [Full Text]  
• Fehniger, T. A., Caligiuri, M. A. (2001). Interleukin 15: biology and relevance to human disease. Blood 97: 14-32 [Full Text]