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Previous Volume 342:1607-1608 May 25, 2000 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Gryfe et al. (Jan. 13 issue)¹ report that microsatellite instability in colorectal cancer is independently predictive of a favorable outcome. We have some concern about this conclusion, since the tumors with microsatellite instability were more frequently localized (59 percent, vs. 38 percent of those with microsatellite stability) and since the 10-year survival at each Dukes' stage did not differ significantly between patients with microsatellite instability and those with microsatellite stability (Figure 2B, 2C, 2D, and 2E in the article). The authors state that in a multivariate analysis, microsatellite status was found to be "significantly and independently" associated . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Samowitz, W. S., Curtin, K., Ma, K.-N., Schaffer, D., Coleman, L. W., Leppert, M., Slattery, M. L. (2001). Microsatellite Instability in Sporadic Colon Cancer Is Associated with an Improved Prognosis at the Population Level. Cancer Epidemiol. Biomarkers Prev. 10: 917-923 [Abstract] [Full Text]