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Neuromuscular diseases comprise a large number of clinically and etiologically diverse disorders affecting the muscle, the neuromuscular junction, the nerve, and the motor neuron. Among them are genetic, autoimmune, toxic, viral, and metabolic diseases. Because of their complexity, the investigation of these diseases necessitates expertise not only in the associated clinical phenomena but also in electrophysiology, muscle morphology, biochemistry, genetics, immunology, and therapeutics. The need to synthesize clinical and laboratory information in order to arrive at the proper diagnosis was conceived in the 1960s at the National Institutes of Health by G. Milton Shy, who began training physicians to become
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