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Correspondence
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Volume 342:1676-1678 June 1, 2000 Number 22
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Unstable Angina Pectoris

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 by The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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 by Yeghiazarians, Y.
To the Editor: Yeghiazarians and colleagues (Jan. 13 issue)1 did not mention 3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitors (statins) in their interesting review of unstable angina pectoris. Evidence from a secondary-prevention study — the Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) study — involving more than 9000 patients, 36 percent of whom had been given a diagnosis of unstable angina between 3 and 36 months before study entry, showed that pravastatin significantly lowered the rate of hospitalization for unstable angina pectoris, with a relative reduction in risk of 12 percent (95 percent confidence interval, 4 to 19 percent; P=0.005).2 This relative . . . [Full Text of this Article]

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