To the Editor: Mild, transient visual changes such as increasedsensitivity to light and color-tinge alterations occur in 3percent of men who take sildenafil.1,2,3 We therefore assessedwhether sildenafil could alter ocular perfusion.
We studied the right-eye responses in 12 normal adults (10 menand 2 women; mean [±SD] age, 36±3 years) beforeand after the oral administration of 50 mg of sildenafil (Viagra,Pfizer, New York). We measured intraocular pressure and pulsatileocular blood flow by analyzing five consecutive tonometric ocularpulse waves (tonometer, OBF Laboratories, Malmesbury, UnitedKingdom), retinal microcirculation by Doppler velocimetry (HRFflowmeter, Heidelberg Engineering, . . . [Full Text of this Article]
References
This article has been cited by other articles:
Harris, A, Kagemann, L, Ehrlich, R, Ehrlich, Y, Lopez, C R, Purvin, V A
(2008). The effect of sildenafil on ocular blood flow. Br J Ophthalmol
92: 469-473
[Abstract][Full Text]
Yuan, Z., Hein, T. W., Rosa, R. H. Jr, Kuo, L.
(2008). Sildenafil (Viagra) Evokes Retinal Arteriolar Dilation: Dual Pathways via NOS Activation and Phosphodiesterase Inhibition. IOVS
49: 720-725
[Abstract][Full Text]
Pache, M., Meyer, P., Prunte, C., Orgul, S., Nuttli, I., Flammer, J.
(2002). Sildenafil induces retinal vasodilatation in healthy subjects. Br J Ophthalmol
86: 156-158
[Abstract][Full Text]
Morgan, J. C., Alhatou, M., Oberlies, J., Johnston, K. C.
(2001). Transient ischemic attack and stroke associated with sildenafil (Viagra) use. Neurology
57: 1730-1731
[Full Text]