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Previous Volume 342:1762 June 8, 2000 Number 23 Next

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By Mel Greaves. 276 pp. New York, Oxford University Press, 2000. $27.50 ISBN 0-19-262835-6.

Cancer is often portrayed as a Darwinian struggle in which a progenitor cell evolves or progresses over a series of hurdles. A recent Medline search returned more than 7000 items on cancer and evolution and more than 27,000 on cancer and progression. However, evolution is a concept much easier to recognize than to define or apply. All living things evolve. The puzzle is which one of a number of plausible or seemingly improbable pathways is taken.

Recent advances allow increasingly fine dissections of the mechanisms underlying cancer. What causes a normal cell to become a killer? Although the final missteps . . . [Full Text of this Article]

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