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Previous Volume 342:1792-1801 June 15, 2000 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The development of coronary artery disease, and specifically myocardial infarction, involves hyperplasia of arterial smooth muscle, the development of fatty streaks, atheroma formation, plaque rupture, and ultimately thrombus formation and vessel occlusion.¹ These changes are in part genetically determined, as demonstrated by the fact that the risk of myocardial infarction in persons who have a first-degree relative with myocardial infarction is seven times the risk in persons who do not.^2,3 This finding is often used to argue that coronary artery disease has a genetic basis, but the extent to which a shared environment contributes to the risk must also be . . . [Full Text of this Article]

Mechanisms in the Formation and Degradation of Fibrin

Formation and Stabilization

Inhibition of Fibrinolysis

Activation of Fibrinolysis

Interaction of PAI-1 and t-PA with Fibrin

Effect of Fibrin Formation on Enzyme-Inhibitor Reactions

PAI-1 in Coronary Artery Disease

PAI-1 and the Progression of Vascular Disease

PAI-1 in Vessel Walls and Plaques

PAI-1 and Cellular Migration

Relation between PAI-1 and Cardiovascular Risk Factors

Regulation of PAI-1

Influence of Glucose and Insulin on the Production of PAI-1

Influence of Estrogen on the Production of PAI-1

The Renin–Angiotensin System

Regulation of PAI-1 Gene Expression

PAI-1 Gene Polymorphisms

PAI-1 Genotype and Coronary Artery Disease

PAI-1, Factor XIII wGenotype, and Insulin Resistance

Conclusions

Source Information

From the Department of Trauma and Emergency Medicine and the Laboratory for Thrombosis Research, Department of Clinical Research, University Hospital of Bern, Inselspital, Bern, Switzerland (H.P.K.); and the Unit of Molecular Vascular Medicine, Leeds General Infirmary, University of Leeds, Leeds, United Kingdom (P.J.G.).

Address reprint requests to Dr. Kohler at the Department of Trauma and Emergency Medicine, University Hospital of Bern, Inselspital, 3010 Bern, Switzerland, or at hanspeter.kohler@insel.ch.

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