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Previous Volume 342:1904-1907 June 22, 2000 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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It has become a cliché to say that sickle cell anemia is the first "molecular disease."¹ The substitution of valine for glycine in ß-globin has been known as the cause of sickle cell anemia since 1957.² That this specific knowledge has not resulted in a rationally designed, specific cure remains a disappointment. What is not disappointing is that the study of sickle hemoglobin and sickle red cells has provided important information about the pathophysiology of the disease, and this information forms the basis for rationally designed clinical care.

The polymerization of sickle hemoglobin is central to the disorder (Figure . . . [Full Text of this Article]

References

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