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Previous Volume 342:1917-1918 June 22, 2000 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We would like to comment on the design and interpretation of the recent study by the Heart Outcomes Prevention Evaluation (HOPE) investigators on vitamin E supplementation and cardiovascular events (Jan. 20 issue).¹ Although this study was undertaken in many geographic areas (the United States, Canada, western Europe, and South America) with different dietary intakes, dietary data (especially on antioxidants) were not reported. In addition, for no subgroup were plasma levels of vitamin E provided to confirm supplementation. Whereas the investigators in the Cambridge Heart Antioxidant Study (CHAOS), the Alpha-Tocopherol, Beta Carotene Cancer Prevention (ATBC) study, and the . . . [Full Text of this Article]

References

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• Gorelick, P. B. (2002). Stroke Prevention Therapy Beyond Antithrombotics: Unifying Mechanisms in Ischemic Stroke Pathogenesis and Implications for Therapy: An Invited Review. Stroke 33: 862-875 [Abstract] [Full Text]  
• Iuliano, L., Micheletta, F., Maranghi, M., Frati, G., Diczfalusy, U., Violi, F. (2001). Bioavailability of Vitamin E as Function of Food Intake in Healthy Subjects: Effects on Plasma Peroxide-Scavenging Activity and Cholesterol-Oxidation Products. Arterioscler. Thromb. Vasc. Bio. 21 : e34-e37 [Abstract] [Full Text]