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Editorial
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Volume 342:1990-1991 June 29, 2000 Number 26
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E. coli, Antibiotics, and the Hemolytic–Uremic Syndrome

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 by Wong, C. S.
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The hemolytic–uremic syndrome is characterized by hemolytic anemia, thrombocytopenia, and acute renal insufficiency. There are at least four major causes of the syndrome: bacterial and viral infections, which are responsible for the epidemic form; hereditary factors, which are responsible for familial forms, in particular recurrent, or atypical, hemolytic–uremic syndrome; systemic conditions, such as systemic lupus erythematosus, cancer, transplant rejection, glomerulonephritis, and pregnancy; and exposure to toxins or potential toxins, such as cyclosporine, tacrolimus, mitomycin, and radiation.1 Among children the chief cause of the hemolytic–uremic syndrome is infection with enterohemorrhagic strains of Escherichia coli. Originally, a variety of serotypes were described . . . [Full Text of this Article]

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