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Previous Volume 342:177-185 January 20, 2000 Number 3 Next

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Parathyroid hormone–related protein was identified in the 1980s as a tumor product that had the ability to activate parathyroid hormone receptors and cause hypercalcemia.¹ Parathyroid hormone–related protein resembles parathyroid hormone not only in terms of its genetic sequence but also in terms of its genetic structure and is thus a second member of the parathyroid hormone family.² As expected of a protein that activates the parathyroid hormone receptor, parathyroid hormone–related protein causes hypercalcemia by increasing bone resorption and renal tubular resorption of calcium.^3,4 Like parathyroid hormone, it also has phosphaturic action.

Parathyroid Hormone–Related Protein and Hypercalcemia

Parathyroid hormone–related protein is the predominant cause of hypercalcemia . . . [Full Text of this Article]

Physiologic Role of Parathyroid Hormone–Related Protein

Development of Cartilage

Mammary Development

Lactation

Tooth Development

Effects on Skin and Hair Follicles

Expression in the Central Nervous System

Specificity of Action

Expression in Placenta

Effects on Smooth Muscle

Conclusions

Source Information

From the Department of Medicine, Veterans Affairs Boston Health Care System, West Roxbury, Mass., and Harvard Medical School, Boston.

References

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