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Previous Volume 342:292-293 January 27, 2000 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In Dr. Shinobu's discussion of Creutzfeldt–Jakob disease in the September 16 Case Records,¹ he implies that cerebrospinal fluid markers have little diagnostic value. In fact, a positive test for 14-3-3 protein in cerebrospinal fluid has now been shown to be an accurate predictor of the disease. Traditionally, the most useful noninvasive study for the diagnosis of sporadic Creutzfeldt–Jakob disease has been electroencephalography, with a characteristic tracing of periodic sharp-wave complexes reported to have a sensitivity of 67 percent and a specificity of 86 percent. However, the test for the 14-3-3 protein in cerebrospinal fluid has a sensitivity . . . [Full Text of this Article]

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