To the Editor: The article by Javaheri (Sept. 23 issue)1 expandsour understanding of the key role of enhanced central chemoreflexsensitivity, including increased ventilatory responsivenessto hyperoxic hypercapnia while awake, in the pathophysiologyof central sleep apnea in patients with congestive heart failure.However, it remains to be determined whether this abnormalityis a predisposing factor for, or a consequence of, the developmentof congestive heart failure.
We reported our observation of increased ventilatory responsesin patients with heart failure and central sleep apnea in 1993,2and we subsequently reported that patients with obstructiveapnea and heart failure had . . . [Full Text of this Article]
References
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