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Previous Volume 342:359-360 February 3, 2000 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: According to the Food and Drug Administration, trovafloxacin, a broad-spectrum quinolone antibiotic, has been associated with more than 100 cases of hepatic toxicity. Fourteen of these cases involved acute liver failure, with transplantation required in four patients; five patients died of liver disease. More than 300,000 prescriptions for trovafloxacin were written monthly in the United States before use of the drug was limited to certain serious infections in an inpatient setting.

There have been a few reports of hepatic toxicity associated with the use of quinolones^1,2,3 but to our knowledge no published reports of toxicity associated with . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Shaw, P. J., Ganey, P. E., Roth, R. A. (2009). Tumor Necrosis Factor{alpha} Is a Proximal Mediator of Synergistic Hepatotoxicity from Trovafloxacin/Lipopolysaccharide Coexposure. J. Pharmacol. Exp. Ther. 328: 62-68 [Abstract] [Full Text]  
• Barequet, I. S., Denton, P., Osterhout, G. J., Tuli, S., O'Brien, T. P. (2004). Treatment of Experimental Bacterial Keratitis With Topical Trovafloxacin. Arch Ophthalmol 122: 65-69 [Abstract] [Full Text]  
• Jaruga, B., Hong, F., Sun, R., Radaeva, S., Gao, B. (2003). Crucial Role of IL-4/STAT6 in T Cell-Mediated Hepatitis: Up-Regulating Eotaxins and IL-5 and Recruiting Leukocytes. J. Immunol. 171: 3233-3244 [Abstract] [Full Text]