Edited by Stephen T. Holgate, Homer A. Boushey, and Leonardo M. Fabbri. 567 pp., illustrated. London, Martin Dunitz, 1999. £65. ISBN 1-85317-556-0.
The clinical syndrome of asthma has been known for more than2000 years, but much about the complex two-way interactionsbetween the immune system and airway epithelium, the effectof the environment, and the underlying pathophysiology of thedisorder remains obscure. For reasons that are not entirelyclear, the prevalence of asthma has increased in the past decade;not only is the burden of the disease increasing, but morbidityand mortality from asthma have also increased in many partsof the world. Most patients with asthma have mild disease, butsome patients have severe asthma that profoundly affects thequality . . . [Full Text of this Article]
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