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Previous Volume 342:438-440 February 10, 2000 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The report by Andreu et al. (Sept. 30 issue)¹ describes a sporadically occurring mitochondrial myopathy in patients with exercise intolerance that is caused by somatic mutations in the cytochrome b gene of mitochondrial DNA. We performed a retrospective analysis of patients with exercise intolerance whose muscle-biopsy specimens were sent to our laboratory for diagnosis. Patients at high risk for the cytochrome b defect were those with deficiencies of complexes I–III, II–III, or both and those with idiopathic mitochondrial myopathy with weakness, fatigue, and evidence of increased mitochondrial content in muscle. Plasma lactate levels were measured too infrequently . . . [Full Text of this Article]

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