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Previous Volume 342:564-571 February 24, 2000 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Each year in the United States, breast cancer is diagnosed in more than 170,000 women.¹ Despite this substantial burden of disease, however, assessment of breast-cancer risk has received very little attention outside the oncology clinic.^2,3 In primary care, the main result of the recognition of individual variation in breast-cancer risk is the use of age to determine recommendations regarding mammography (older age is a strong risk factor for breast cancer).⁴

Recent developments in the ability to predict and alter breast-cancer risk warrant a new look at the role of assessment of this risk in primary care. Physicians must become adept . . . [Full Text of this Article]

Why Evaluate Breast-Cancer Risk?

Decisions about Postmenopausal Hormone-Replacement Therapy

Decisions about the Use of Mammography for Women 40 to 49 Years of Age

Decisions about the Use of Tamoxifen for the Prevention of Breast Cancer

Decisions about Prophylactic Mastectomy

How to Evaluate Breast-Cancer Risk

Average Risk

Epidemiologic Risk Factors

Risk-Prediction Models

Genetic-Susceptibility Testing

Selecting a Prediction Method

Source Information

From the Department of Medicine (K.A., A.E., B.W.) and the Center for Clinical Epidemiology and Biostatistics (K.A.), University of Pennsylvania School of Medicine; the University of Pennsylvania Cancer Center (K.A., A.E., B.W.); and the Leonard Davis Institute of Health Economics, University of Pennsylvania (K.A.) — all in Philadelphia.

Address reprint requests to Dr. Armstrong at 1233 Blockley Hall, 423 Guardian Dr., Philadelphia, PA 19104-6021, or at karmstro@mail.med.upenn.edu.

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