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Previous Volume 342:587-589 February 24, 2000 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their review article, Sakane et al. (Oct. 21 issue)¹ asserted that the more severe clinical features of Behçet's disease, such as ocular and central nervous system involvement, are commonly associated with the presence of the HLA-B51 allele. It is generally accepted that the HLA-B51 allele is more common in patients with Behçet's disease than in the general population. However, HLA-B51 positivity generally does not determine the prognosis and response to therapy. A comparative study from Turkey and the United Kingdom found no association between the presence of the HLA-B51 allele and clinical severity of disease.² The . . . [Full Text of this Article]

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