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Previous Volume 342:651-653 March 2, 2000 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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It is not often that two seemingly separate lines of investigation converge to yield both a new insight into the pathogenesis of a disease and possibilities for clinical applications. Such is the case with an article by He et al., who report that the chemopreventive effects of nonsteroidal antiinflammatory drugs on colorectal cancer involve the interaction of the adenomatous polyposis coli (APC) tumor-suppressor pathway and the nuclear hormone receptor peroxisome-proliferator–activated receptor (PPAR).¹ Their study establishes a molecular link between the genetics of colonic neoplasia and the mechanism by which nonsteroidal antiinflammatory drugs can prevent colorectal cancer. This effect of . . . [Full Text of this Article]

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