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Previous Volume 342:661 March 2, 2000 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Mølbak et al. (Nov. 4 issue)¹ call attention to disparities between the results of in vitro tests of ciprofloxacin sensitivity in salmonella and treatment failure. The evolution of antibiotic resistance most often occurs in vivo, and some resistance factors may be promoted by this environment. Exciting results have emerged from the application of in vivo expression technology (IVET) to the discovery of virulence factors.² In many of those experiments, antibiotic resistance has been used as a reporting mechanism for IVET-related gene expression. This approach might obscure the possibility that resistance itself may sometimes be an in vivo–limited . . . [Full Text of this Article]

References

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• Stephenson, I., Nicholson, K.G. (2001). Influenza: vaccination and treatment. Eur Respir J 17: 1282-1293 [Abstract] [Full Text]  
• Snell, N. J. C. (2001). New treatments for viral respiratory tract infections--opportunities and problems. J Antimicrob Chemother 47: 251-259 [Full Text]  
• Wright, P. (2000). Influenza in the Family. NEJM 343: 1331-1332 [Full Text]