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Previous Volume 343:69-70 July 6, 2000 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Hershey, G. K. K.

To the Editor: In 1997, Hershey et al. reported finding a mutation in the interleukin-4 receptor allele in 13 of 20 patients with atopy, as compared with 5 of 30 control subjects.¹ This mutation (termed Q576R) increases the signaling function of the interleukin-4 receptor, thereby favoring the expression of IgE receptors on immune cells.

We studied 75 patients with atopic dermatitis or asthma and 150 control subjects for the presence of the Q576R mutation. Wild-type and mutant alleles were amplified by the polymerase chain reaction with modified primers and segregated after enzymatic digestion with AvaI and electrophoretic migration. We . . . [Full Text of this Article]

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