The New England Journal of Medicine
e-mail icon  FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
Correspondence
PreviousPrevious
Volume 343:72 July 6, 2000 Number 1
NextNext

Inhibition of Megakaryopoiesis by Kell-Related Antibodies

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

 Sign up for free e-toc
 

This Article
-Full Text
-Purchase this article

Tools and Services
-Add to Personal Archive
-Add to Citation Manager
-Notify a Friend
-E-mail When Cited

More Information
-PubMed Citation
To the Editor: Kell, one of the major red-cell groups in humans, comprises 22 antigens. These antigens are encoded by alleles on chromosome 7, including sets of antithetical antigens such as Kell (K) and Cellano (k), which differ by a single amino acid.1 Anti-Kell antibodies have been shown to suppress the growth of erythroid progenitor cells in a semisolid culture system.2 This finding has been linked to the reticulocytopenia that is usual in hemolytic disease of the newborn (erythroblastosis neonatorum) induced by anti-Kell antibodies.3 We recently observed substantial thrombocytopenia in three fetuses with erythroblastosis fetalis due to anti-Kell antibodies (platelet . . . [Full Text of this Article]

References


This article has been cited by other articles:



HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  TERMS OF USE  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2009 Massachusetts Medical Society. All rights reserved.