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Previous Volume 343:710-722 September 7, 2000 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Ischemic stroke exacts a heavy toll in death and disability worldwide. In the United States, where it is the third leading cause of death and the leading cause of serious long-term disability, approximately 750,000 strokes occur annually, with an annual mortality rate exceeding 150,000.^1,2,3,4

In June 1996, the Food and Drug Administration (FDA) approved tissue plasminogen activator (t-PA) as a safe and effective treatment for stroke if it is given within three hours after the onset of symptoms of stroke.⁵ Subsequently, results of large clinical trials testing the efficacy of antiplatelet, antithrombotic, and neuroprotective treatments appeared. More recently, intraarterial thrombolytic . . . [Full Text of this Article]

Pathophysiology and Targets for Intervention

Early Evaluation and Supportive Treatment

Intravenous Thrombolytic Therapy

Intraarterial Thrombolytic Therapy

Antithrombotic and Antiplatelet Drugs

Heparin

Aspirin

Ancrod

Neuroprotection

Treatment in the Hospital

Integrated Stroke-Intervention Teams and Stroke Units

Rehabilitation

Conclusions

Source Information

From the Department of Neurology, Mayo Clinic, Jacksonville, Fla. (T.B.); and the Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (J.B.).

Address reprint requests to Dr. Brott at the Department of Neurology, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, or at brott.thomas@mayo.edu.

References

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