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Volume 343:815 September 14, 2000 Number 11
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Propylene Glycol Toxicity in a Patient Receiving Intravenous Diazepam

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To the Editor: Alcohol withdrawal is a common problem among hospitalized patients and is frequently treated with intravenous diazepam. Propylene glycol is a solvent in which diazepam is often dissolved for intravenous infusion. We report a case of nearly fatal propylene glycol toxicity in a patient receiving intravenous diazepam for the treatment of alcohol withdrawal.

A 46-year-old man with alcoholism was admitted to the hospital with painless facial swelling attributed to angioedema. On the second hospital day, agitation, fever, flushing, tachycardia, hypertension, and tremulousness developed. Because of presumed alcohol withdrawal, he was treated with intravenous diazepam and received approximately 3000 . . . [Full Text of this Article]

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