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Correspondence
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Volume 343:891 September 21, 2000 Number 12
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Excess Iron Storage in Patients with Type 2 Diabetes Unrelated to Primary Hemochromatosis

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To the Editor: The discovery of mutations in the HFE gene in patients with hemochromatosis has made possible earlier or more complete ascertainment of cases of this disease.1 Diabetes mellitus is one manifestation of hemochromatosis, but in several studies, the frequency of HFE mutations was similar in normal subjects and in patients with type 2 diabetes.2

We analyzed exons 2 and 4 of the HFE gene by sequencing in 19 patients with primary hemochromatosis and in the 5 patients, of a total of 551 with type 2 diabetes, who had a positive biochemical screening test for hemochromatosis (serum transferrin saturation, >=. . . [Full Text of this Article]

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