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Hairy-cell leukemia has been the subject of more scientific reports than its rarity might warrant. Many early studies dealt with the morphologic characteristics of hairy cells, the pathological features of involved tissues, tartrate-resistant acid phosphatase as a marker, the cellular lineage of hairy cells, the clinical response to splenectomy, and the dramatic results of treatment with interferon, pentostatin, and cladribine. We now know that cells with "hairs" may not be hairy cells. This cytologic feature may prevail in phorbol esterstimulated chronic lymphocytic leukemia cells and in splenic lymphoma with villous lymphocytes.
Variants of hairy-cell leukemia include the blastic subtype, the
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