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Previous Volume 343:938-952 September 28, 2000 Number 13 Next

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More than 100 years has passed since Charcot, Carswell, Cruveilhier, and others described the clinical and pathological characteristics of multiple sclerosis.¹ This enigmatic, relapsing, and often eventually progressive disorder of the white matter of the central nervous system continues to challenge investigators trying to understand the pathogenesis of the disease and prevent its progression.² There are 250,000 to 350,000 patients with multiple sclerosis in the United States.³ Multiple sclerosis typically begins in early adulthood and has a variable prognosis. Fifty percent of patients will need help walking within 15 years after the onset of disease.⁴ Advanced magnetic resonance imaging (MRI) . . . [Full Text of this Article]

Clinical Course and Diagnosis

Epidemiologic Features

Genetic Factors

Pathological Features and Pathogenesis

Treatment

Principles of Therapy

Relapses

Relapsing Multiple Sclerosis

Secondary Progressive Multiple Sclerosis

Primary Progressive Multiple Sclerosis and the Management of Symptoms

Treatment of Complications

Challenges in Conducting Clinical Trials and Future Directions

Source Information

From the Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minn.

Address reprint requests to Dr. Noseworthy at the Department of Neurology, Mayo Clinic and Mayo Foundation, 200 First St., SW, Rochester, MN 55905.

References

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