More than 100 years has passed since Charcot, Carswell, Cruveilhier,and others described the clinical and pathological characteristicsof multiple sclerosis.1 This enigmatic, relapsing, and ofteneventually progressive disorder of the white matter of the centralnervous system continues to challenge investigators trying tounderstand the pathogenesis of the disease and prevent its progression.2There are 250,000 to 350,000 patients with multiple sclerosisin the United States.3 Multiple sclerosis typically begins inearly adulthood and has a variable prognosis. Fifty percentof patients will need help walking within 15 years after theonset of disease.4 Advanced magnetic resonance imaging (MRI). . . [Full Text of this Article]
Clinical Course and Diagnosis
Epidemiologic Features
Genetic Factors
Pathological Features and Pathogenesis
Treatment
Principles of Therapy
Relapses
Relapsing Multiple Sclerosis
Secondary Progressive Multiple Sclerosis
Primary Progressive Multiple Sclerosis and the Management of Symptoms
Treatment of Complications
Challenges in Conducting Clinical Trials and Future Directions
Source Information
From the Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minn.
Address reprint requests to Dr. Noseworthy at the Department of Neurology, Mayo Clinic and Mayo Foundation, 200 First St., SW, Rochester, MN 55905.
References
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[Abstract][Full Text]
Chen, J. W., Breckwoldt, M. O., Aikawa, E., Chiang, G., Weissleder, R.
(2008). Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis. Brain
131: 1123-1133
[Abstract][Full Text]
Sicotte, N. L., Kern, K. C., Giesser, B. S., Arshanapalli, A., Schultz, A., Montag, M., Wang, H., Bookheimer, S. Y.
(2008). Regional hippocampal atrophy in multiple sclerosis. Brain
131: 1134-1141
[Abstract][Full Text]
Skripuletz, T., Lindner, M., Kotsiari, A., Garde, N., Fokuhl, J., Linsmeier, F., Trebst, C., Stangel, M.
(2008). Cortical Demyelination Is Prominent in the Murine Cuprizone Model and Is Strain-Dependent. Am. J. Pathol.
172: 1053-1061
[Abstract][Full Text]
Leigh, R. J., Serra, A.
(2008). Taking the temperature of MS with INO. Neurology
70: 1063-1064
[Full Text]
Villar, L., Garcia-Barragan, N., Espino, M., Roldan, E., Sadaba, M., Gomez-Rial, J., Gonzalez-Porque, P., Alvarez-Cermeno, J.
(2008). Influence of oligoclonal IgM specificity in multiple sclerosis disease course. Mult Scler
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[Abstract]
Tsutsui, S., Vergote, D., Shariat, N., Warren, K., Ferguson, S. S. G., Power, C.
(2008). Glucocorticoids regulate innate immunity in a model of multiple sclerosis: reciprocal interactions between the A1 adenosine receptor and {beta}-arrestin-1 in monocytoid cells. FASEB J.
22: 786-796
[Abstract][Full Text]
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(2008). Multiple Sclerosis: Pathogenesis and MR Imaging Features of T1 Hypointensities in Murine Model. Radiology
246: 790-795
[Abstract][Full Text]
Soilu-Hanninen, M, Laaksonen, M, Laitinen, I, Eralinna, J-P, Lilius, E-M, Mononen, I
(2008). A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry
79: 152-157
[Abstract][Full Text]
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(2008). Fast Progression of Recombinant Human Myelin/Oligodendrocyte Glycoprotein (MOG)-Induced Experimental Autoimmune Encephalomyelitis in Marmosets Is Associated with the Activation of MOG34-56-Specific Cytotoxic T Cells. J. Immunol.
180: 1326-1337
[Abstract][Full Text]
Minagar, A., Alexander, J. S., Schwendimann, R. N., Kelley, R. E., Gonzalez-Toledo, E., Jimenez, J. J., Mauro, L., Jy, W., Smith, S. J.
(2008). Combination Therapy With Interferon Beta-1a and Doxycycline in Multiple Sclerosis: An Open-Label Trial. Arch Neurol
65: 199-204
[Abstract][Full Text]
Frohman, E. M., Zivadinov, R.
(2007). What you see is what you get: Coupling function with structure in the visual system. Neurology
69: 2119-2120
[Full Text]
Rocca, M. A., Pagani, E., Absinta, M., Valsasina, P., Falini, A., Scotti, G., Comi, G., Filippi, M.
(2007). Altered functional and structural connectivities in patients with MS: A 3-T study. Neurology
69: 2136-2145
[Abstract][Full Text]
Gundogan, F. C., Demirkaya, S., Sobaci, G.
(2007). Is Optical Coherence Tomography Really a New Biomarker Candidate in Multiple Sclerosis? A Structural and Functional Evaluation. IOVS
48: 5773-5781
[Abstract][Full Text]
Pohlau, D., Przuntek, H., Sailer, M., Bethke, F., Koehler, J., Konig, N., Heesen, C., Spath, P., Andresen, I.
(2007). Intravenous immunoglobulin in primary and secondary chronic progressive multiple sclerosis: a randomized placebo controlled multicentre study. Mult Scler
13: 1107-1117
[Abstract]
Dutta, R., McDonough, J., Chang, A., Swamy, L., Siu, A., Kidd, G. J., Rudick, R., Mirnics, K., Trapp, B. D.
(2007). Activation of the ciliary neurotrophic factor (CNTF) signalling pathway in cortical neurons of multiple sclerosis patients. Brain
130: 2566-2576
[Abstract][Full Text]
Calabrese, M., De Stefano, N., Atzori, M., Bernardi, V., Mattisi, I., Barachino, L., Morra, A., Rinaldi, L., Romualdi, C., Perini, P., Battistin, L., Gallo, P.
(2007). Detection of Cortical Inflammatory Lesions by Double Inversion Recovery Magnetic Resonance Imaging in Patients With Multiple Sclerosis. Arch Neurol
64: 1416-1422
[Abstract][Full Text]
Williams, A., Piaton, G., Aigrot, M.-S., Belhadi, A., Theaudin, M., Petermann, F., Thomas, J.-L., Zalc, B., Lubetzki, C.
(2007). Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis?. Brain
130: 2554-2565
[Abstract][Full Text]
Yu, K.-H., Yang, C.-H., Chu, C.-C.
(2007). Swallowing disturbance due to isolated vagus nerve involvement in systemic lupus erythematosus. Lupus
16: 746-749
[Abstract]
Trojan, D., Arnold, D., Collet, J-P., Shapiro, S., Bar-Or, A., Robinson, A., Le Cruguel, J-P., Ducruet, T., Narayanan, S., Arcelin, K., Wong, A., Tartaglia, M., Lapierre, Y., Caramanos, Z., Da Costa, D.
(2007). Fatigue in multiple sclerosis: association with disease-related, behavioural and psychosocial factors. Mult Scler
13: 985-995
[Abstract]
Sobocki, P., Pugliatti, M., Lauer, K., Kobelt, G.
(2007). Estimation of the cost of MS in Europe: Extrapolations from a multinational cost study. Mult Scler
13: 1054-1064
[Abstract]
Rose, J. W., Burns, J. B., Bjorklund, J., Klein, J., Watt, H. E., Carlson, N. G.
(2007). Daclizumab phase II trial in relapsing and remitting multiple sclerosis: MRI and clinical results. Neurology
69: 785-789
[Abstract][Full Text]
Shindler, K. S., Ventura, E., Rex, T. S., Elliott, P., Rostami, A.
(2007). SIRT1 Activation Confers Neuroprotection in Experimental Optic Neuritis. IOVS
48: 3602-3609
[Abstract][Full Text]
GOVARTS, C., SOMERS, K., HUPPERTS, R., STINISSEN, P., SOMERS, V.
(2007). Exploring cDNA Phage Display for Autoantibody Profiling in the Serum of Multiple Sclerosis Patients: Optimization of the Selection Procedure. Ann. N. Y. Acad. Sci.
1109: 372-384
[Abstract][Full Text]
Glass-Marmor, L., Paperna, T., Ben-Yosef, Y., Miller, A.
(2007). Chronotherapy using corticosteroids for multiple sclerosis relapses. J. Neurol. Neurosurg. Psychiatry
78: 886-888
[Abstract][Full Text]
Nessler, S., Boretius, S., Stadelmann, C., Bittner, A., Merkler, D., Hartung, H.-P., Michaelis, T., Bruck, W., Frahm, J., Sommer, N., Hemmer, B.
(2007). Early MRI changes in a mouse model of multiple sclerosis are predictive of severe inflammatory tissue damage. Brain
130: 2186-2198
[Abstract][Full Text]
Greer, D. M., Cagliero, E., Krakauer, E. L., Gonzalez, R. G., Hedley-Whyte, E. T.
(2007). Case 21-2007 -- A 58-Year-Old Woman with Headaches, Weakness, and Strokelike Episodes. NEJM
357: 164-173
[Full Text]
Pelayo, R., Tintore, M., Rovira, A., Rio, J., Nos, C., Grive, E., Tellez, N., Comabella, M., Montalban, X.
(2007). Polyregional and hemispheric syndromes: a study of these uncommon first attacks in a CIS cohort. Mult Scler
13: 731-736
[Abstract]
Alanoglu, G., Kilbas, S., Arslan, C., Senol, A., Kutluhan, S.
(2007). Autoimmune hemolytic anemia during interferon-beta-I b treatment for multiple sclerosis. Mult Scler
13: 683-685
[Abstract]
Rossi, C., Padmanaban, D., Ni, J., Yeh, L.-A., Glicksman, M. A., Waldner, H.
(2007). Identifying Druglike Inhibitors of Myelin-Reactive T Cells by Phenotypic High-Throughput Screening of a Small-Molecule Library. J Biomol Screen
12: 481-489
[Abstract]
Dutta, R., Trapp, B. D.
(2007). Pathogenesis of axonal and neuronal damage in multiple sclerosis. Neurology
68: S22-S31
[Abstract][Full Text]
Hamamcioglu, K., Reder, A.
(2007). Interferon-{beta} regulates cytokines and BDNF: greater effect in relapsing than in progressive multiple sclerosis. Mult Scler
13: 459-470
[Abstract]
Martinez, A., Sanchez-Lopez, M., Varade, J., Mas, A., Carmen Martin, M, de las Heras, V., Arroyo, R., Luis Mendoza, J., Diaz-Rubio, M., Fernandez-Gutierrez, B., de la Concha, E. G, Urcelay, E.
(2007). Role of the MHC2TA gene in autoimmune diseases. Ann Rheum Dis
66: 325-329
[Abstract][Full Text]
Benito, C., Romero, J. P., Tolon, R. M., Clemente, D., Docagne, F., Hillard, C. J., Guaza, C., Romero, J.
(2007). Cannabinoid CB1 and CB2 Receptors and Fatty Acid Amide Hydrolase Are Specific Markers of Plaque Cell Subtypes in Human Multiple Sclerosis. J. Neurosci.
27: 2396-2402
[Abstract][Full Text]
Dunn, S. E., Ousman, S. S., Sobel, R. A., Zuniga, L., Baranzini, S. E., Youssef, S., Crowell, A., Loh, J., Oksenberg, J., Steinman, L.
(2007). Peroxisome proliferator-activated receptor (PPAR){alpha} expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. J. Exp. Med.
204: 321-330
[Abstract][Full Text]
Mameli, G., Astone, V., Arru, G., Marconi, S., Lovato, L., Serra, C., Sotgiu, S., Bonetti, B., Dolei, A.
(2007). Brains and peripheral blood mononuclear cells of multiple sclerosis (MS) patients hyperexpress MS-associated retrovirus/HERV-W endogenous retrovirus, but not Human herpesvirus 6. J. Gen. Virol.
88: 264-274
[Abstract][Full Text]
Amend, B., Doster, H., Lange, C., Dubois, E., Kalbacher, H., Melms, A., Bischof, F.
(2006). Induction of Autoimmunity by Expansion of Autoreactive CD4+CD62Llow Cells In Vivo. J. Immunol.
177: 4384-4390
[Abstract][Full Text]
Gladstone, D. E., Zamkoff, K. W., Krupp, L., Peyster, R., Sibony, P., Christodoulou, C., Locher, E., Coyle, P. K.
(2006). High-Dose Cyclophosphamide for Moderate to Severe Refractory Multiple Sclerosis. Arch Neurol
63: 1388-1393
[Abstract][Full Text]
Kappos, L., Antel, J., Comi, G., Montalban, X., O'Connor, P., Polman, C. H., Haas, T., Korn, A. A., Karlsson, G., Radue, E. W., the FTY720 D2201 Study Group,
(2006). Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis. NEJM
355: 1124-1140
[Abstract][Full Text]
Shindler, K. S, Guan, Y., Ventura, E., Bennett, J., Rostami, A.
(2006). Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis. Mult Scler
12: 526-532
[Abstract]
Zwemmer, J N., Berkhof, J, Castelijns, J A, Barkhof, F, Polman, C H, Uitdehaag, B M.
(2006). Classification of multiple sclerosis patients by latent class analysis of magnetic resonance imaging characteristics. Mult Scler
12: 565-572
[Abstract]
Shriver, L. P., Dittel, B. N.
(2006). T-Cell-Mediated Disruption of the Neuronal Microtubule Network: Correlation with Early Reversible Axonal Dysfunction in Acute Experimental Autoimmune Encephalomyelitis. Am. J. Pathol.
169: 999-1011
[Abstract][Full Text]
Mikaeloff, Y., Caridade, G., Assi, S., Suissa, S., Tardieu, M., on behalf of the KIDSEP Study Group,
(2006). Prognostic Factors for Early Severity in a Childhood Multiple Sclerosis Cohort. Pediatrics
118: 1133-1139
[Abstract][Full Text]
Herrmann, I., Kellert, M., Schmidt, H., Mildner, A., Hanisch, U. K., Bruck, W., Prinz, M., Nau, R.
(2006). Streptococcus pneumoniae Infection Aggravates Experimental Autoimmune Encephalomyelitis via Toll-Like Receptor 2.. Infect. Immun.
74: 4841-4848
[Abstract][Full Text]
Rinaldi, L., Gallo, P., Calabrese, M., Ranzato, F., Luise, D., Colavito, D., Motta, M., Guglielmo, A., Del Giudice, E., Romualdi, C., Ragazzi, E., D'Arrigo, A., Dalle Carbonare, M., Leontino, B., Leon, A.
(2006). Longitudinal analysis of immune cell phenotypes in early stage multiple sclerosis: distinctive patterns characterize MRI-active patients.. Brain
129: 1993-2007
[Abstract][Full Text]
Friese, M. A., Montalban, X., Willcox, N., Bell, J. I., Martin, R., Fugger, L.
(2006). The value of animal models for drug development in multiple sclerosis. Brain
129: 1940-1952
[Abstract][Full Text]
Lehmann, H. C., Hartung, H.-P., Hetzel, G. R., Stuve, O., Kieseier, B. C.
(2006). Plasma exchange in neuroimmunological disorders: part 1: rationale and treatment of inflammatory central nervous system disorders.. Arch Neurol
63: 930-935
[Abstract][Full Text]
Fahey, A. J., Robins, R. A., Kindle, K. B., Heery, D. M., Constantinescu, C. S.
(2006). Effects of glucocorticoids on STAT4 activation in human T cells are stimulus-dependent. J. Leukoc. Biol.
80: 133-144
[Abstract][Full Text]
Nielsen, N. M., Westergaard, T., Frisch, M., Rostgaard, K., Wohlfahrt, J., Koch-Henriksen, N., Melbye, M., Hjalgrim, H.
(2006). Type 1 diabetes and multiple sclerosis: a danish population-based cohort study.. Arch Neurol
63: 1001-1004
[Abstract][Full Text]
Rauer, S, Euler, B, Reindl, M, Berger, T
(2006). Antimyelin antibodies and the risk of relapse in patients with a primary demyelinating event.. J. Neurol. Neurosurg. Psychiatry
77: 739-742
[Abstract][Full Text]
Rajda, C, Bencsik, K, Fuvesi, J, Seres, E, Vecsei, L, Bergquist, J
(2006). The norepinephrine level is decreased in the lymphocytes of long-term interferon-beta-treated multiple sclerosis patients. Mult Scler
12: 265-270
[Abstract]
Alonso, A., Jick, S. S., Jick, H., Hernan, M. A.
(2006). Antibiotic Use and Risk of Multiple Sclerosis. Am J Epidemiol
163: 997-1002
[Abstract][Full Text]
Dousset, V., Brochet, B., Deloire, M.S.A., Lagoarde, L., Barroso, B., Caille, J.-M., Petry, K.G.
(2006). MR Imaging of Relapsing Multiple Sclerosis Patients Using Ultra-Small-Particle Iron Oxide and Compared with Gadolinium.. Am. J. Neuroradiol.
27: 1000-1005
[Abstract][Full Text]
Pittock, S. J., Weinshenker, B. G., Noseworthy, J. H., Lucchinetti, C. F., Keegan, M., Wingerchuk, D. M., Carter, J., Shuster, E., Rodriguez, M.
(2006). Not every patient with multiple sclerosis should be treated at time of diagnosis.. Arch Neurol
63: 611-614
[Full Text]
Dimitri, D., Benveniste, O., Dubourg, O., Maisonobe, T., Eymard, B., Amoura, Z., Jean, L., Tiev, K., Piette, J.-C., Klatzmann, D., Herson, S., Boyer, O.
(2006). Shared blood and muscle CD8+ T-cell expansions in inclusion body myositis. Brain
129: 986-995
[Abstract][Full Text]
Paintlia, A. S., Paintlia, M. K., Singh, I., Singh, A. K.
(2006). IL-4-Induced Peroxisome Proliferator-Activated Receptor {gamma} Activation Inhibits NF-{kappa}B Trans Activation in Central Nervous System (CNS) Glial Cells and Protects Oligodendrocyte Progenitors under Neuroinflammatory Disease Conditions: Implication for CNS-Demyelinating Diseases. J. Immunol.
176: 4385-4398
[Abstract][Full Text]
Paran, D, Chapman, J, Korczyn, A D, Elkayam, O, Hilkevich, O, Groozman, G B, Levartovsky, D, Litinsky, I, Caspi, D, Segev, Y, Drory, V E
(2006). Evoked potential studies in the antiphospholipid syndrome: differential diagnosis from multiple sclerosis. Ann Rheum Dis
65: 525-528
[Abstract][Full Text]
Frohman, E. M., Racke, M. K., Raine, C. S.
(2006). Multiple sclerosis--the plaque and its pathogenesis.. NEJM
354: 942-955
[Full Text]
Confavreux, C., Vukusic, S.
(2006). Age at disability milestones in multiple sclerosis. Brain
129: 595-605
[Abstract][Full Text]
Yue, T., Xian, K., Hurlock, E., Xin, M., Kernie, S. G., Parada, L. F., Lu, Q. R.
(2006). A Critical Role for Dorsal Progenitors in Cortical Myelination. J. Neurosci.
26: 1275-1280
[Abstract][Full Text]
Samijn, J P A, te Boekhorst, P A W, Mondria, T, van Doorn, P A, Flach, H Z, van der Meche, F G A, Cornelissen, J, Hop, W C, Lowenberg, B, Hintzen, R Q
(2006). Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosis. J. Neurol. Neurosurg. Psychiatry
77: 46-50
[Abstract][Full Text]
Imitola, J., Chitnis, T., Khoury, S. J.
(2006). Insights Into the Molecular Pathogenesis of Progression in Multiple Sclerosis: Potential Implications for Future Therapies. Arch Neurol
63: 25-33
[Abstract][Full Text]
Powell, N. D., Papenfuss, T. L., McClain, M. A., Gienapp, I. E., Shawler, T. M., Satoskar, A. R., Whitacre, C. C.
(2005). Cutting Edge: Macrophage Migration Inhibitory Factor Is Necessary for Progression of Experimental Autoimmune Encephalomyelitis. J. Immunol.
175: 5611-5614
[Abstract][Full Text]
Wiendl, H., Feger, U., Mittelbronn, M., Jack, C., Schreiner, B., Stadelmann, C., Antel, J., Brueck, W., Meyermann, R., Bar-Or, A., Kieseier, B. C., Weller, M.
(2005). Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity. Brain
128: 2689-2704
[Abstract][Full Text]
Kutzelnigg, A., Lucchinetti, C. F., Stadelmann, C., Bruck, W., Rauschka, H., Bergmann, M., Schmidbauer, M., Parisi, J. E., Lassmann, H.
(2005). Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain
128: 2705-2712
[Abstract][Full Text]
Berger, T., Deisenhammer, F., Alvarez-Cermeno, J. C., Masjuan, J., Villar, L. M., Kleinschmidt-DeMasters, B.K., Tyler, K. L., Langer-Gould, A., Atlas, S. W., Pelletier, D.
(2005). Progressive multifocal leukoencephalopathy, natalizumab, and multiple sclerosis.. NEJM
353: 1744-1746
[Full Text]
Nielsen, N. M., Westergaard, T., Rostgaard, K., Frisch, M., Hjalgrim, H., Wohlfahrt, J., Koch-Henriksen, N., Melbye, M.
(2005). Familial Risk of Multiple Sclerosis: A Nationwide Cohort Study. Am J Epidemiol
162: 774-778
[Abstract][Full Text]
Hansen, T, Skytthe, A, Stenager, E, Petersen, H C, Bronnum-Hansen, H, Kyvik, K O
(2005). Concordance for multiple sclerosis in Danish twins: an update of a nationwide study. Mult Scler
11: 504-510
[Abstract]
Haas, J, Maas-Enriquez, M, Hartung, H P
(2005). Intravenous immunoglobulins in the treatment of relapsing remitting multiple sclerosis - results of a retrospective multicenter observational study over five years. Mult Scler
11: 562-567
[Abstract]
Lisanti, C. J., Asbach, P., Bradley, W. G. Jr.
(2005). The Ependymal "Dot-Dash" Sign: An MR Imaging Finding of Early Multiple Sclerosis. Am. J. Neuroradiol.
26: 2033-2036
[Abstract][Full Text]
Herrmann, M. M., Gaertner, S., Stadelmann, C., van den Brandt, J., Boscke, R., Budach, W., Reichardt, H. M., Weissert, R.
(2005). Tolerance induction by bone marrow transplantation in a multiple sclerosis model. Blood
106: 1875-1883
[Abstract][Full Text]
Dandekar, A. A., O'Malley, K., Perlman, S.
(2005). Important Roles for Gamma Interferon and NKG2D in {gamma}{delta} T-Cell-Induced Demyelination in T-Cell Receptor {beta}-Deficient Mice Infected with a Coronavirus. J. Virol.
79: 9388-9396
[Abstract][Full Text]
Sloka, J S, Stefanelli, M
(2005). The mechanism of action of methylprednisolone in the treatment of multiple sclerosis. Mult Scler
11: 425-432
[Abstract]
Friese, M. A., Fugger, L.
(2005). Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?. Brain
128: 1747-1763
[Abstract][Full Text]
Soilu-Hanninen, M., Koskinen, J. O., Laaksonen, M., Hanninen, A., Lilius, E. -M., Waris, M.
(2005). High sensitivity measurement of CRP and disease progression in multiple sclerosis. Neurology
65: 153-155
[Abstract][Full Text]
Cepok, S., Rosche, B., Grummel, V., Vogel, F., Zhou, D., Sayn, J., Sommer, N., Hartung, H.-P., Hemmer, B.
(2005). Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis. Brain
128: 1667-1676
[Abstract][Full Text]
Sfagos, C., Makis, A. C, Chaidos, A., Hatzimichael, E. C, Dalamaga, A., Kosma, K., Bourantas, K. L.
(2005). Serum ferritin, transferrin and soluble transferrin receptor levels in multiple sclerosis patients. Mult Scler
11: 272-275
[Abstract]
Jimenez, J. J, Jy, W., Mauro, L. M, Horstman, L. L, Ahn, E. R, Ahn, Y. S, Minagar, A.
(2005). Elevated endothelial microparticle--monocyte complexes induced by multiple sclerosis plasma and the inhibitory effects of interferon-{beta}1b on release of endothelial microparticles, formation and transendothelial migration of monocyte-endothelial microparticle complexes. Mult Scler
11: 310-315
[Abstract]
FILIPOVIC, R., ZECEVIC, N.
(2005). Interaction between Microglia and Oligodendrocyte Cell Progenitors Involves Golli Proteins. Ann. N. Y. Acad. Sci.
1048: 166-174
[Abstract][Full Text]
MINAGAR, A., ADAMASHVILLI, I., JAFFE, S. L., GLABUS, M. F., GONZALEZ-TOLEDO, E., KELLEY, R. E.
(2005). Soluble HLA Class I and Class II Molecules in Relapsing-Remitting Multiple Sclerosis: Acute Response to Interferon-{beta}1a Treatment and Their Use as Markers of Disease Activity. Ann. N. Y. Acad. Sci.
1051: 111-120
[Abstract][Full Text]
Burt, R. K., Cohen, B., Rose, J., Petersen, F., Oyama, Y., Stefoski, D., Katsamakis, G., Carrier, E., Kozak, T., Muraro, P. A., Martin, R., Hintzen, R., Slavin, S., Karussis, D., Haggiag, S., Voltarelli, J. C., Ellison, G. W., Jovanovic, B., Popat, U., McGuirk, J., Statkute, L., Verda, L., Haas, J., Arnold, R.
(2005). Hematopoietic Stem Cell Transplantation for Multiple Sclerosis. Arch Neurol
62: 860-864
[Full Text]
Yadav, V, Marracci, G, Lovera, J, Woodward, W, Bogardus, K, Marquardt, W, Shinto, L, Morris, C, Bourdette, D
(2005). Lipoic acid in multiple sclerosis: a pilot study. Mult Scler
11: 159-165
[Abstract]
Patwardhan, M B, Matchar, D B, Samsa, G P, McCrory, D C, Williams, R G, Li, T T
(2005). Cost of multiple sclerosis by level of disability: a review of literature. Mult Scler
11: 232-239
[Abstract]
Ferreira, S., D'Cruz, D. P., Hughes, G. R. V.
(2005). Multiple sclerosis, neuropsychiatric lupus and antiphospholipid syndrome: where do we stand?. Rheumatology (Oxford)
44: 434-442
[Abstract][Full Text]
Kim, T. S., Perlman, S.
(2005). Virus-Specific Antibody, in the Absence of T Cells, Mediates Demyelination in Mice Infected with a Neurotropic Coronavirus. Am. J. Pathol.
166: 801-809
[Abstract][Full Text]