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A 39-year-old man and a 52-year-old woman with Huntington's disease of 8 and 13 years' duration, respectively, were hospitalized because of agitation, aggression, and delusions that had begun 2 to 3 years earlier. In the year before admission, their uncontrollable movements had become so severe that they could not walk or assist in their own care. Both had received haloperidol
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