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Previous Volume 343:1020-1034 October 5, 2000 Number 14 Next

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Since the pioneering work of Gowans and colleagues in the 1960s,^1,2 much progress has been made in understanding the pivotal role of cell migration in immunity. We now have considerable knowledge of the way in which specialized leukocytes are channeled to distinct target tissues in immune responses and inflammation (Figure 1). This review will concentrate on the migration of T cells, which are at the heart of most adaptive immune responses.

View larger version (98K): [in this window] [in a new window]   Figure 1. Migratory Routes of T Cells. Naive T cells home continuously from the blood to lymph nodes and other secondary lymphoid tissues. Homing to lymph nodes occurs in . . . [Full Text of this Article]

 
The Career of a T Cell

Microvascular Determinants of T-Cell Recruitment

Adhesion Molecules

Chemokines

Multistep Adhesion Cascades

Homing of Naive T Cells to Lymphoid Tissues

Migration of Dendritic Cells

Activation of T Cells and Cooperation between T Cells and B Cells

Migration of Effector T Cells

Homing to Nonlymphoid Tissues

Immune Surveillance by Memory T Cells

Viral Assault on Homing Molecules

Clinical Applications

Future Directions

Source Information

From the Center for Blood Research, Department of Pathology, Harvard Medical School, Boston (U.H.A.); and the Garvan Institute of Medical Research, Darlinghurst, N.S.W., Australia (C.R.M.).

Address reprint requests to Dr. von Andrian at the Center for Blood Research, 200 Longwood Ave., Boston, MA 02115, or at uva@cbr.med.harvard.edu.

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