The compartmentalization of functions into distinct membrane-boundorganelles is a central characteristic of cells. The proteinand lipid composition of these organelles is unique, a factorthat is vital for their proper function. This necessitates tightlycontrolled transport of biomolecules from their sites of synthesisor uptake to specific destinations, and mechanisms that preventpromiscuous interactions between cellular membranes that wouldlead to deleterious mixing of organelle constituents. One ofthe major processes responsible for the correct localizationof molecules within the cell is called membrane or vesiculartransport. In this process, membranous carrier structures budoff a donor compartment . . . [Full Text of this Article]
Intracellular-Membrane Transport
Sorting of Proteins to Transport Vesicles
Cytoskeletal Tracks for the Movement of Vesicles
Fusion of Transport Vesicles with Target Membranes
Inherited Diseases Characterized by Defects in Intracellular Protein Transport
Defects Affecting the Protein-Sorting Apparatus
Defects in Cytoskeletal Proteins Involved in Membrane Transport
Defects in the Machinery for the Docking and Fusion of Transport Vesicles
Lipid Disorders Affecting Vesicular Transport
Conclusions
Source Information
From the Department of Biochemistry, National Public Health Institute, Helsinki, Finland.
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