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Previous Volume 343:1125 October 12, 2000 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Treatment of children may be difficult because of a shortage of properly formulated or approved drugs.¹ In the Netherlands and elsewhere, many drugs are not approved for use in children, and some drugs are often used outside the terms of the product's approval (off-label use). We studied the unapproved and off-label use of drugs in a children's hospital in which the hospital pharmacy, unlike pharmacies in many other European countries, is allowed to prepare "homemade" formulations and to modify commercial preparations in order to suit the needs of children.

During a five-week period, we classified the use . . . [Full Text of this Article]

References

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• Zuppa, A. F., Adamson, P. C., Mondick, J. T., Davis, L. A., Maka, D. A., Narayan, M., Nicholson, C., Patel, D., Collison, K. R., Barrett, J. S. (2005). Drug Utilization in the Pediatric Intensive Care Unit: Monitoring Prescribing Trends and Establishing Prioritization of Pharmacotherapeutic Evaluation of Critically Ill Children. J Clin Pharmacol 45: 1305-1312 [Abstract] [Full Text]  
• Hill, P (2005). Off licence and off label prescribing in children: litigation fears for physicians. Arch. Dis. Child. 90: i17-i18 [Abstract] [Full Text]  
• Roberts, R., Rodriguez, W., Murphy, D., Crescenzi, T. (2003). Pediatric Drug Labeling: Improving the Safety and Efficacy of Pediatric Therapies. JAMA 290: 905-911 [Abstract] [Full Text]  
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• Schirm, E., Tobi, H., de Jong-van den Berg, L. T W (2002). Unlicensed and off label drug use by children in the community: cross sectional study. BMJ 324: 1312-1313 [Full Text]  
• 't Jong, G. W., Vulto, A. G., de Hoog, M., Schimmel, K. J. M., Tibboel, D., van den Anker, J. N. (2001). A Survey of the Use of Off-Label and Unlicensed Drugs in a Dutch Children's Hospital. Pediatrics 108: 1089-1093 [Abstract] [Full Text]