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Previous Volume 343:1197-1198 October 19, 2000 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The pituitary gonadotropins luteinizing hormone and follicle-stimulating hormone regulate the ovarian production of sex steroids. According to the two-cell–two-gonadotropin theory, luteinizing hormone stimulates thecal cells to produce androgens, and follicle-stimulating hormone stimulates granulosa cells to produce estrogens from androgens. Follicle-stimulating hormone is thought to have little effect on thecal-cell androgen production.¹ We investigated these concepts by studying the effect of gonadotropins on ovarian steroid secretion in a woman with isolated follicle-stimulating hormone deficiency due to compound heterozygous mutations of the gene for the ß-subunit of follicle-stimulating hormone.

The patient had initially presented at the age of 16 . . . [Full Text of this Article]

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