FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 343:1342 November 2, 2000 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

To the Editor: A 21-year-old man presented with a three-year history of worsening dyspnea and a four-month history of being unable to walk more than 100 yards (90 m) without resting. Physical examination revealed signs of pulmonary hypertension. A chest radiograph showed the typical changes associated with primary pulmonary hypertension. An echocardiogram obtained at the time of admission showed marked right ventricular dilatation; the estimated pulmonary-artery systolic pressure was 120 mm Hg (resulting from tricuspid regurgitation identified on Doppler ultrasonography). Left ventricular systolic function was preserved.

Pulmonary-function tests showed only mild airflow limitation. A computed tomographic scan of the thorax . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Cheng, J. W. M., Berhane, S. R. (2009). Managing Erectile Dysfunction in Patients With Cardiovascular Diseases: The Efficacy and Safety of Phosphodiesterase-5 Inhibitors. AMERICAN JOURNAL OF LIFESTYLE MEDICINE 3: 201-211 [Abstract]  
• Dhaygude, A., MacDowall, P., Coward, R. A., Woywodt, A. (2009). Out of the blue. NDT Plus 2: 67-71 [Full Text]  
• Klodell, C. T. Jr, Morey, T. E., Lobato, E. B., Aranda, J. M. Jr, Staples, E. D., Schofield, R. S., Hess, P. J., Martin, T. D., Beaver, T. M. (2007). Effect of Sildenafil on Pulmonary Artery Pressure, Systemic Pressure, and Nitric Oxide Utilization in Patients With Left Ventricular Assist Devices. Ann. Thorac. Surg. 83: 68-71 [Abstract] [Full Text]  
• Hsu, A. R., Barnholt, K. E., Grundmann, N. K., Lin, J. H., McCallum, S. W., Friedlander, A. L. (2006). Sildenafil improves cardiac output and exercise performance during acute hypoxia, but not normoxia. J. Appl. Physiol. 100: 2031-2040 [Abstract] [Full Text]  
• Newman, J. H. (2005). Pulmonary Hypertension. Am. J. Respir. Crit. Care Med. 172: 1072-1077 [Abstract] [Full Text]  
• Ford, K. (2005). Pulmonary artery hypertension: new drug treatment in children. EDUCATION AND PRACTICE 90: ep15-ep20 [Full Text]  
• Das, A., Xi, L., Kukreja, R. C. (2005). Phosphodiesterase-5 Inhibitor Sildenafil Preconditions Adult Cardiac Myocytes against Necrosis and Apoptosis: ESSENTIAL ROLE OF NITRIC OXIDE SIGNALING. J. Biol. Chem. 280: 12944-12955 [Abstract] [Full Text]  
• Humbert, M. (2005). Improving survival in pulmonary arterial hypertension. Eur Respir J 25: 218-220 [Full Text]  
• Richalet, J.-P., Gratadour, P., Robach, P., Pham, I., Dechaux, M., Joncquiert-Latarjet, A., Mollard, P., Brugniaux, J., Cornolo, J. (2005). Sildenafil Inhibits Altitude-induced Hypoxemia and Pulmonary Hypertension. Am. J. Respir. Crit. Care Med. 171: 275-281 [Abstract] [Full Text]  
• Trachte, A. L., Lobato, E. B., Urdaneta, F., Hess, P. J., Klodell, C. T., Martin, T. D., Staples, E. D., Beaver, T. M. (2005). Oral Sildenafil Reduces Pulmonary Hypertension After Cardiac Surgery. Ann. Thorac. Surg. 79: 194-197 [Abstract] [Full Text]  
• Task Force members, , Galie, N., Torbicki, A., Barst, R., Dartevelle, P., Haworth, S., Higenbottam, T., Olschewski, H., Peacock, A., Pietra, G., Rubin, L. J., Simonneau, G. (2004). Guidelines on diagnosis and treatment of pulmonary arterial hypertension: The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology. Eur Heart J 25: 2243-2278 [Full Text]  
• Kloner, R. A. (2004). Cardiovascular Effects of the 3 Phosphodiesterase-5 Inhibitors Approved for the Treatment of Erectile Dysfunction. Circulation 110: 3149-3155 [Full Text]  
• Palmieri, E. A., Affuso, F., Fazio, S., Lembo, D. (2004). Tadalafil in Primary Pulmonary Arterial Hypertension. ANN INTERN MED 141: 743-744 [Full Text]  
• Humbert, M., Sitbon, O., Simonneau, G. (2004). Treatment of Pulmonary Arterial Hypertension. NEJM 351: 1425-1436 [Full Text]  
• Gomez-Sanchez, M. A., de la Calzada, C. S., Subias, P. E., Jimenez, J. F. D., Salvador, M. L., Gonzalez, A. A., Calvo, L. C. (2004). Pilot assessment of the response of several pulmonary hemodynamic variables to sublingual sildenafil in candidates for heart transplantation. Eur J Heart Fail 6: 615-617 [Abstract] [Full Text]  
• Galie, N., Seeger, W., Naeije, R., Simonneau, G., Rubin, L. J. (2004). Comparative analysis of clinical trials and evidence-based treatment algorithm in pulmonary arterial hypertension. J Am Coll Cardiol 43: 81S-88S [Abstract] [Full Text]  
• Sastry, B. K. S., Narasimhan, C., Reddy, N. K., Raju, B. S. (2004). Clinical efficacy of sildenafil in primary pulmonary hypertension: A randomized, placebo-controlled, double-blind, crossover study. J Am Coll Cardiol 43: 1149-1153 [Abstract] [Full Text]  
• Mikhail, G. W, Prasad, S. K, Li, W., Rogers, P., Chester, A. H, Bayne, S., Stephens, D., Khan, M., Gibbs, J.S.R, Evans, T. W, Mitchell, A., Yacoub, M. H, Gatzoulis, M. A (2004). Clinical and haemodynamic effects of sildenafil in pulmonary hypertension: acute and mid-term effects. Eur Heart J 25: 431-436 [Abstract] [Full Text]  
• Leuchte, H. H., Schwaiblmair, M., Baumgartner, R. A., Neurohr, C. F., Kolbe, T., Behr, J. (2004). Hemodynamic Response to Sildenafil, Nitric Oxide, and Iloprost in Primary Pulmonary Hypertension. Chest 125: 580-586 [Abstract] [Full Text]  
• Matot, I., Gozal, Y. (2004). Pulmonary Responses to Selective Phosphodiesterase-5 and Phosphodiesterase-3 Inhibitors. Chest 125: 644-651 [Abstract] [Full Text]  
• Humbert, M., Simonneau, G. (2004). Sildenafil for Pulmonary Arterial Hypertension: Still Waiting for Evidence. Am. J. Respir. Crit. Care Med. 169: 6-7 [Full Text]  
• Schermuly, R. T., Kreisselmeier, K. P., Ghofrani, H. A., Yilmaz, H., Butrous, G., Ermert, L., Ermert, M., Weissmann, N., Rose, F., Guenther, A., Walmrath, D., Seeger, W., Grimminger, F. (2004). Chronic Sildenafil Treatment Inhibits Monocrotaline-induced Pulmonary Hypertension in Rats. Am. J. Respir. Crit. Care Med. 169: 39-45 [Abstract] [Full Text]  
• Rosenkranz, S., Diet, F., Karasch, T., Weihrauch, J., Wassermann, K., Erdmann, E. (2003). Sildenafil Improved Pulmonary Hypertension and Peripheral Blood Flow in a Patient with Scleroderma-Associated Lung Fibrosis and the Raynaud Phenomenon. ANN INTERN MED 139: 871-873 [Full Text]  
• Bhatia, S., Frantz, R. P., Severson, C. J., Durst, L. A., McGoon, M. D. (2003). Immediate and Long-term Hemodynamic and Clinical Effects of Sildenafil in Patients With Pulmonary Arterial Hypertension Receiving Vasodilator Therapy. Mayo Clin Proc. 78: 1207-1213 [Abstract]  
• Carroll, W D, Dhillon, R (2003). Sildenafil as a treatment for pulmonary hypertension. Arch. Dis. Child. 88: 827-828 [Abstract] [Full Text]  
• Rybalkin, S. D., Yan, C., Bornfeldt, K. E., Beavo, J. A. (2003). Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function. Circ. Res. 93: 280-291 [Abstract] [Full Text]  
• Humbert, M., Sitbon, O., Simonneau, G. (2003). Novel therapeutic perspectives in pulmonary arterial hypertension. Eur Respir J 22: 193-194 [Full Text]  
• Reffelmann, T., Kloner, R. A. (2003). Therapeutic Potential of Phosphodiesterase 5 Inhibition for Cardiovascular Disease. Circulation 108: 239-244 [Full Text]  
• Sharma, S. (2003). Treatment of Pulmonary Arterial Hypertension: A Step Forward. Chest 124: 8-11 [Full Text]  
• Molina, J, Lucero, E, Luluaga, S, Bellomio, V, Spindler, A, Berman, A (2003). Systemic lupus erythematosus-associated pulmonary hypertension: good outcome following sildenafil therapy. Lupus 12: 321-323 [Abstract]  
• Mehta, S. (2003). Sildenafil for Pulmonary Arterial Hypertension: Exciting, But Protection Required. Chest 123: 989-992 [Full Text]  
• Stiebellehner, L., Petkov, V., Vonbank, K., Funk, G., Schenk, P., Ziesche, R., Block, L.-H. (2003). Long-term Treatment With Oral Sildenafil in Addition to Continuous IV Epoprostenol in Patients With Pulmonary Arterial Hypertension. Chest 123: 1293-1295 [Abstract] [Full Text]  
• Widlitz, A., Barst, R.J. (2003). Pulmonary arterial hypertension in children. Eur Respir J 21: 155-176 [Abstract] [Full Text]  
• Jackson, G. (2002). Phosphodiesterase type 5 inhibition in cardiovascular disease: experimental models and potential clinical applications. Eur Heart J Suppl 4: H19-H23 [Abstract]  
• Galie, N., Manes, A., Branzi, A. (2002). The new clinical trials on pharmacological treatment in pulmonary arterial hypertension. Eur Respir J 20: 1037-1049 [Abstract] [Full Text]  
• Littera, R., La Nasa, G., Derchi, G., Cappellini, M. D., Chang, C. Y. P., Contu, L. (2002). Long-term treatment with oral sildenafil in a thalassemic patient with pulmonary hypertension. Blood 100: 1516-1517 [Full Text]  
• Evans, T W, Gatzoulis, M A, Gibbs, J S R (2002). A National Pulmonary Hypertension Service for England & Wales: an orphan disease is adopted?. Thorax 57: 471-472 [Full Text]  
• Michelakis, E., Tymchak, W., Lien, D., Webster, L., Hashimoto, K., Archer, S. (2002). Oral Sildenafil Is an Effective and Specific Pulmonary Vasodilator in Patients With Pulmonary Arterial Hypertension: Comparison With Inhaled Nitric Oxide. Circulation 105: 2398-2403 [Abstract] [Full Text]  
• Hoeper, M. M., Galie, N., Simonneau, G., Rubin, L. J. (2002). New Treatments for Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med. 165: 1209-1216 [Full Text]  
• Ghofrani, H. A., Wiedemann, R., Rose, F., Olschewski, H., Schermuly, R. T., Weissmann, N., Seeger, W., Grimminger, F. (2002). Combination Therapy with Oral Sildenafil and Inhaled Iloprost for Severe Pulmonary Hypertension. ANN INTERN MED 136: 515-522 [Abstract] [Full Text]  
• Newman, J. H. (2002). Treatment of Primary Pulmonary Hypertension -- The Next Generation. NEJM 346: 933-935 [Full Text]  
• WILKINS, M. R, WHARTON, J. (2001). Progress in, and future prospects for, the treatment of primary pulmonary hypertension. Heart 86: 603-604 [Full Text]  
• Wilkens, H., Guth, A., Konig, J., Forestier, N., Cremers, B., Hennen, B., Bohm, M., Sybrecht, G. W. (2001). Effect of Inhaled Iloprost Plus Oral Sildenafil in Patients With Primary Pulmonary Hypertension. Circulation 104: 1218-1222 [Abstract] [Full Text]  
• (2001). Robin Goodfellow. Rheumatology (Oxford) 40: 240-240 [Full Text]