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Editorial
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Volume 343:1408-1409 November 9, 2000 Number 19
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Pharmacogenomics — Teaching Old Drugs New Tricks

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 by Esteller, M.
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Traditionally, cancer treatments have been selected on the basis of tumor type, pathological features, clinical stage, the patient's age and performance status, and other nonmolecular considerations. We have generally accepted with a certain fatalism that some patients pigeonholed into a given category will have a response to a particular therapy, whereas others will not. The difference is often viewed as a matter of luck, like the result of a coin toss, but in fact, treatment response can be predicted in some cases, whereas it is close to impossible to predict the results of a coin toss. The field of pharmacogenomics, . . . [Full Text of this Article]

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