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Primary and secondary bone marrowfailure disorders have disparate causes, yet many of them have similar clinical presentations. The features of many of these disorders are frequently so nonspecific on routine studies of peripheral blood and bone marrow that it is difficult to establish the correct diagnosis without the aid of one or more definitive cytogenetic, phenotypic, immunologic, or molecular genetic studies. Cognizant of this problem, Young, who is chief of the Hematology Branch of the National Heart, Lung, and Blood Institute of the National Institutes of Health, and 12 colleagues have compiled descriptions of the 10 most common bone marrowfailure
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