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Previous Volume 343:1654-1656 November 30, 2000 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Vassallo et al. (June 29 issue)¹ depict a central role for the alveolar macrophage in the pathogenesis of pulmonary Langerhans'-cell histiocytosis. We made several observations in a series of five patients with biopsy-proved, CD1a+ pulmonary Langerhans'-cell histiocytosis at our institution. The patients were all young adults (age range, 22 to 31 years) who had smoked cigarettes. On histologic analyses, there were CD68+ histiocytes, including macrophages with "smoker's granules," admixed with Langerhans' cells; angiotensin-converting–enzyme (ACE) antigen was expressed on non–Langerhans'-cell histiocytes within the lesion and surrounding alveoli. Histiocytes from a lesion of Langerhans'-cell histiocytosis were positive for the . . . [Full Text of this Article]

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