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Previous Volume 343:1658-1659 November 30, 2000 Number 22 Next

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To the Editor: In October 1998, the Centers for Disease Control and Prevention reported 20 endotoxin-like reactions to intravenous gentamicin¹ administered in a once-daily dosing regimen. We report on a completed investigation of a series of pyrogenic reactions involving two gentamicin products. The reactions were reported to the Food and Drug Administration (FDA) between May 1998 and December 1999. They involved 155 patients; 38 percent were male and 62 percent were female. Their mean age was 41 years (range, 3 to 85). Dosing information was available for 91 percent of the patients (Figure 1). Eighty-one percent received once-daily . . . [Full Text of this Article]

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